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2.47–25.96), and cancer history (RR 3.73, 95% CI 1.28–10.88) at baseline
predicted disability in men only. Women with diabetes (RR 2.97,
95% CI 1.66–5.32), stroke history (RR 2.89, 95% CI 1.07–7.85), and
bodily pain (RR 1.95, 95% CI 1.11–3.41) had higher risk of incident
disability.
CONCLUSIONS: Older women and men with multimorbidity
had different risk factors for incident disability. Among them, several
factors were potentially modifiable. Early screening and targeted intervention
among multimorbid older adults may prevent or delay
disability.
C53
D as in Death - Dietary Vitamin D in Mid-Life and Total Mortality:
The Honolulu Heart Program.
G. Kojima, 1 F. Lui, 1 R. Chen, 2 C. Bell, 1 R. D. Abbott, 1 L. Launer, 4
G. W. Ross, 3,1 J. D. Curb, 1,2 K. H. Masaki. 1,2 1. The John A. Hartford
Foundation Center of Excellence in Geriatrics, Department of
Geriatric Medicine, University of Hawaii, Honolulu, HI; 2. Kuakini
Medical Center, Honolulu, HI; 3. Veterans Affairs Pacific Islands
Healthcare System, Honolulu, HI; 4. National Institute on Aging,
Bethesda, MD.
Supported By: The National Heart, Lung, and Blood Institute; the
National Institute on Aging; Veterans Affairs Pacific Islands
Healthcare Systems; John A. Hartford Foundation Center of
Excellence in Geriatrics, University of Hawaii.
Background:
Low serum vitamin D levels are associated with total mortality
in previous epidemiological studies. Little is known about effects of
dietary vitamin D intake on mortality. We examined the association
between mid-life dietary vitamin D intake and 45-year total mortality
in Japanese-American men.
Methods
The Honolulu Heart Program is a longitudinal cohort study of
8,006 Japanese-American men in Hawaii aged 45-68 at baseline in
1965-68. Mid-life dietary vitamin D intake was calculated from 24-
hour dietary recall using the Nutritionist IV v3 software. Subjects
were divided into quartiles of vitamin D intake. Data on total mortality
were available for up to 45 years, through December 2010. Cox
proportional hazards models were used, and analyses were also stratified
for hypertension (HTN) status.
Results
There were 6,972 deaths during the 45 years of follow-up. Ageadjusted
total mortality rates were higher in the lower 3 quartiles of
dietary vitamin D intake compared to the highest (p for trend=0.011).
In Cox regression models, there was a significant inverse association
between dietary vitamin D quartiles and mortality; quartile (Q) 1
hazard ratio (HR)=1.14, 95%CI=1.07-1.22, p30
days, 90 days after last MDS, death, or end of study).
Results: A total of 2144 VTE On Admission cases were identified,
accounting for 3.7% of all admissions (95% CI: 3.5–3.9%). A
total of 757 cases of VTE During Residence were identified (from an
est. 20,586 person–years [PY] at risk), yielding an incidence of 3.68
cases/100 PY During Residence (95% CI: 3.42–3.95). [See table for
full results] Conclusions: VTE incidence during admission and residence
was common in this population; the latter was higher than previously
reported in LTC studies. Furthermore, this rate was 6 times
higher than a similar-age community cohort.1 These incidence rates
merit further investigation as diagnostic improvements may be driving
greater recognition of VTE in LTC.
1. White RH. Circulation 2003;107(23 suppl 1):I4-8.
VTE Incidence by Age Group (95% CI)
C55
TITLE: Vitamin D Levels and Asssociation with Chronic Medical
Conditions in Home Based Primary Care (HBPC).
H. Moiduddin, 1,2 S. N. Imam, 1,2 A. Imran, 1,2 L. Medina Munoz, 1
T. Lee, 1 Q. Syed, 1 P. Karumanchi. 1 1. Geriatrics and Extended Care,
Edward Hines Veterans Hospital, Hines, IL; 2. Internal Medicine,
Loyola University Medical Center, Maywood, IL.
Background: Numerous studies suggest that Vitamin D deficiency
is commonplace in the United States and the world at large.
The homebound and frail elderly are at high risk for having Vitamin
D deficiency. Recent research confirms that Vitamin D deficiency
contributes to many common conditions other than the musculoskeletal
system disorders to include falls, chronic pain, diabetes
mellitus, hypertension, depression, cancer and increased overall mortality.
Several studies have shown reduced fall risk with Vitamin D
supplementation and also possible improvement in control of chronic
pain, hypertension, diabetes mellitus, and depression. Despite all this
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