programma & abstracts - Nederlandse Vereniging voor Radiologie

RC
research naam corner sessie 1
UMC Groningen
SCREENING FOR CORONARY ARTERY
DISEASE BY NON-INVASIVE IMAGING
IN PATIENTS WITH KNOWN EXTRA-
CARDIAC ATHEROSCLEROTIC DISEASE: THE
GROUND-2 STUDY
R. Vliegenthart 1 , M. Oudkerk 1 , M.A.M. Dekker 1 ,
J.J.A.M. van den Dungen 2 , R.A. Tio 3 , W.P.Th.M. Mali 4 ,
M.M.J.J.R. Jaspers 5
1
Center for Medical Imaging – North East Netherlands
(CMINEN), Dept of Radiology, University Medical Center
Groningen/University of Groningen, Groningen
2
Dept of Surgery, University Medical Center Groningen/
University of Groningen, Groningen
3
Dept of Cardiology, University Medical Center Groningen/
University of Groningen, Groningen
4
Dept of Radiology, University Medical Center Utrecht,
Utrecht
5
Dept of Radiology, Deventer Hospital, Deventer
Patients with extra-cardiac atherosclerosis, like claudication,
carotid stenosis or aortic aneurysm, have an increased risk
of coronary heart disease. The purpose of the GROUND-2
study is to non-invasively evaluate the presence of asymptomatic
coronary artery disease (CAD) by CT calcium scoring,
coronary CT angiography (CTA) and adenosine perfusion cardiac
magnetic resonance imaging (APMR) in case of known
extra-cardiac atherosclerosis.
This study is designed as a prospective multicenter study.
Patients aged 50 and over, diagnosed with extra-coronary
atherosclerosis, either stenotic or aneurysmatic, are eligible
to participate. Exclusion criteria are a history of symptomatic
cardiac disease, severe arterial hypertension and contraindications
to the used imaging modalities. All patients will
non-contrast CT scanning to evaluate the coronary calcium
score. In case of a zero calcium score, patients will be followed.
In all other cases, CTA will be performed to evaluate
the coronary arteries for significant stenoses. In case of a
calcium score above 1000, the CTA is bypassed.
Next, APMR will be used to assess perfusion defects of the
myocardium. If there is a left main stenosis or equivalent on
CTA or a perfusion defect on APMR, the patient will be referred
to a cardiologist for further evaluation and treatment.
All patients will be followed for 5 years for the occurrence
of events.
In this multicenter study, at least 1030 patients will be
included. Inclusion has started in December 2009. This study
will provide insight into the prevalence of silent severe
CAD, detected by non-invasive cardiac imaging, in patients
with known extra-cardiac atherosclerosis. Radiological
screening for asymptomatic CAD may improve survival in
these patients. Preliminary results indicate that significant
coronary atherosclerosis is prevalent in patient with known
extracoronary atherosclerosis.
VUMC
PSEUDO-CONTINUOUS ARTERIAL SPIN
LABELING AT 3T IN ALZHEIMER’S DISEASE -
INITIAL EXPERIENCE IN A MEMORY CLINIC
M.A.A. Binnewijzend, J.P.A. Kuijer, M.R. Benedictus,
P.J. Visser, W.M. van der Flier, M.P. Wattjes, P. Scheltens,
F.A. Barkhof
3D pseudo-continuous arterial spin labeling (PCASL) is a
non-invasive scan technique that measures cerebral blood
flow (CBF). We aimed to compare CBF of subjects with
Alzheimer’s disease (AD), mild cognitive impairment (MCI)
and subjective memory complaints (SMC).
MRI scans, including MPRAGE and 3D-PCASL (post-label
delay 2.0s, 3D-FSE, TR=4.8s, TE=4.7ms, spiral readout 8
arms x 512 samples; 36x5.0mm axial slices; total scan time
4min) were acquired on a 3T GE HDxt scanner in 76 consecutive
subjects (33 AD, 15 MCI, 28 SMC) that visited our
memory clinic. Partial volume estimates were obtained from
MPRAGE images (using the FAST algorithm, part of FSL) to
create CBF maps corrected for partial volume effects. Gray
matter (GM) CBF-values were compared using analyses-ofvariance.
Correlations with cognition (MMSE-scores) and
vascular white matter lesions (WML) were investigated
using linear regression analyses, correcting for age and
gender.
Four subjects (1 AD, 2 MCI, 1 SMC) were excluded from
further analyses because of poor scan quality. Compared
to SMC subjects, GM-CBF was decreased in both MCI
(43±7 vs. 50±8 ml/100g/min; p