programma & abstracts - Nederlandse Vereniging voor Radiologie

Sessie 2
Abdominale radiologie/
Acute radiologie/Diversen
2
Abdominale radiologie/
Acute radiologie/Diversen
Donderdag 29 september, 14.05 - 15.35 uur
O2.1
DYNAMIC CONTRAST ENHANCED MRI FOR
THE EVALUATION OF PERIANAL FISTULAS
IN PATIENTS WITH CROHN’S DISEASE
M.L.W. Ziech, C. Lavini, C.Y. Ponsioen, M.W.A. Caan,
S. Bipat, A.M. Spijkerboer, P. Stokkers, A.J. Nederveen,
J. Stoker
Academisch Medisch Centrum, Amsterdam
Purpose: To determine if dynamic contrast enhanced MRI
(DCE-MRI) can evaluate disease activity in patients with
perianal fistulizing Crohn’s disease.
Methods and materials: Patients with perianal fistulizing
Crohn’s disease, underwent DCE-MRI. The van Assche
MRI-based score and perianal disease activity index (PDAI)
were determined. Transversal DCE-MRI was performed at 3T
during intravenous contrast injection (TE 2.3, TR 5.1, FA 30,
15 slices, total duration of dynamic scan 5.05 min, 70 scans
per slice, temporal resolution 4.2 sec per volume).
The qualitative parameters Maximum Enhancement (ME),
slope of the enhancement curve (SoE) and curve shape type
(as by Lavini et al), as well as the quantitative parameters
Ktrans, Vep, Kep as in the Tofts model were calculated
(using a measured arterial input function) on a pixel by pixel
basis, and then averaged of over an ROI drawn around the
fistula. Spearman correlations between DCE-MRI parameters
and PDAI and MRI-based score were calculated.
Results: Sixteen patients (7 males) were included, mean
age 37 (range 18-63). PDAI correlated with ME (r=0.669,
p=0.005), SoE (r=0.582, p=0.018), ROI volume (r=0.786,
p