programma & abstracts - Nederlandse Vereniging voor Radiologie

posterpresentaties
P
Table 1: Presence and distribution of SpA-features.
P14
FEASIBILITY OF FUNCTIONAL IMAGING,
INCLUDING DYNAMIC CONSTRAST-
ENHANCED MRI AND PERFUSION CT,
FOR POST-CHEMORADIOTHERAPEUTIC
RESTAGING IN RECTAL CANCER PATIENTS
S.J. Klieverik, E. Kluza, M. Maas, R.G.H. Beets-Tan, G. Beets,
D.M.J. Lambregts
Maastricht Universitair Medisch Centrum, Maastricht
Aim: The aim of this study was to perform a review of the
literature to determine whether 1) the current literature
reports correlations between functional imaging and clinicopathological
markers in rectal cancer patients and 2) if
functional imaging is sensitive to chemoradiotherapy (CRT)-
induced changes in rectal cancer.
Methods: The literature of interest was searched using
Pubmed. Studies were included when correlations between
functional and clinicopathological markers and differences
in functional parameters between pre- and post-CRT were
reported.
Results: Five studies used dynamic constrast-enhanced MRI
(DCE-MRI) and two studies used perfusion CT (p-CT) to
investigate the correlation between functional and clinicopathological
markers. Two studies compared functional parameters
from DCE-MRI in CRT responders vs. non-responders.
Studies correlating DCE-MRI parameters with clinicopathological
markers showed that higher endothelial transfer
coefficient (Ktrans) and perfusion index (PI; a measure of
both perfusion and cappilary permeability surface product)
were significantly correlated with more advanced cancer
stages (e.g. TNM stage) and that these functional parameters
were significantly higher before treatment in patients
with a good response to CRT than in non-responders. Two
studies evaluated the correlation between p-CT parameters
and clinicopathological parameters. Results showed that
significantly higher blood volume, blood flow and mean
transit time were found in groups with poor prognosis (e.g.
high MVD, existence of lympathic metastasis). There were
no studies comparing p-CT parameter in a pre vs. post-CRT
setting.
Conclusion: The reviewed literature shows that functional
imaging parameters, especially Ktrans in DCE-MRI and
BV and BF in p-CT, correlate with clinical and pathological
markers. Therefore, both DCE-MRI and p-CT are of great
potentional as non-invasive therapy-monitoring or therapypredicting
methods in rectal cancer.
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