programma & abstracts - Nederlandse Vereniging voor Radiologie

8
programma abstracts & abstracts
O8.3
RESPONSE EVALUATION OF NEOADJUVANT
CHEMOTHERAPY IN MAMMACARCINOMA:
ASSOCIATION OF CHANGES IN MRI
DYNAMIC GADOLINEUM ENHANCEMENT
AND DIFFUSION WEIGHTED IMAGING (DWI)
V.H.P. Tran, M.H.M. Volmerink, A.L.T. Imholz,
R.A.J.M. van Dijk
Deventer Ziekenhuis, Deventer
Background: Monitoring tumour response in neoadjuvant
chemotherapy in mammacarcinoma is based on MRI dynamic
gadolineum enhancement. However, the role of DWI in
tumour response monitoring remains to be established.
Methods: In this retrospective study, (changes in) apparent
diffusion coefficient (ADC) after three cycles of neoadjuvant
chemotherapy in 29 consecutive patients treated in our hospital
between 2006 and 2010 were compared to changes
in tumour size measured by RECIST, cross sectional area of
tumour (both early enhancement), and diameter of gadolineum
washout.
Results: Following chemotherapy, ADC increased from
1,44*10 -3 mm 2 /sec (SD0,37*10 -3 ) to 1,69*10 -3 mm 2 /sec
(SD0,40*10 -3 ; Student’s t-test p