programma & abstracts - Nederlandse Vereniging voor Radiologie

posterpresentaties
P
P03
BRAIN PLASTICITY IN APHASIC PATIENTS
AFTER MELODIC INTONATION THERAPY
ASSESSED WITH FUNCTIONAL MAGNETIC
RESONANCE IMAGING (FMRI)
M.A.H. Bechan 1 , W.M.E. van de Sandt-Koenderman 2 ,
C.P. Mendez 1 , E.G. Visch-Brink 1 , M. Smits 1
1
Erasmus Medisch Centrum, Rotterdam
2
Rijndam revalidatiecentrum, Rotterdam
Purpose: Certain aphasic patients are treated with Melodic
Intonation Therapy (MIT), which uses musical elements of
speech to initiate language production. The purpose of this
study is to visualize neuronal reorganizational processes in
the brain in response to MIT using fMRI.
Methods and materials: Four patients with chronic and
two with acute aphasia (22-67 years; 4 males; 5 righthanded)
were scanned at 3T before and after six weeks of
MIT, which consisted of naming, repeating and spontaneous
speech. To visualize language processing a block design
task, consisting of listening to stories versus reverse speech,
was used. Language performance was measured using the
Sabadel story telling task. Imaging data were analyzed
using Statistical Parametric Mapping 8 (London, UK). After
preprocessing individual statistical t-contrast maps were
calculated for pre- and post-therapy datasets. Lateralization
indices (LI) were calculated using the number of significantly
(p