programma & abstracts - Nederlandse Vereniging voor Radiologie

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programma Abstracts & abstracts
Figure 1: ROC-curves for assessment of a CR.
O1.8
WHOLE-BODY MRI, INCLUDING DIFFUSION-
WEIGHTED IMAGING, FOR STAGING NEWLY
DIAGNOSED LYMPHOMA: COMPARISON
TO COMPUTED TOMOGRAPHY IN 101
PATIENTS
T.C. Kwee 1 , M.A. Vermoolen 1 , E.M. Akkerman 2 ,
M.J. Kersten 2 , R. Fijnheer 3 , I. Ludwig 1 , F.J. Beek 1 ,
M.S. van Leeuwen 1 , M.B. Bierings 1 , J. Zsiros 2 ,
H.M.E. Quarles van Ufford 1 , J.M.H. de Klerk 3 , J. Adam 2 ,
J. Stoker 2 , C.S.P. Uiterwaal 1 , R.A.J. Nievelstein 1
1
Universitair Medisch Centrum Utrecht, Utrecht
2
Academisch Medisch Centrum, Amsterdam
3
Meander Medisch Centrum, Amersfoort
Purpose: To compare whole-body magnetic resonance
imaging (MRI), including diffusion-weighted imaging (DWI),
to computed tomography (CT) for staging newly diagnosed
lymphoma.
30.7% (31/101), and lower in 4.0% (4/101) of patients, with
correct/incorrect/unresolved overstaging and incorrect/
unresolved understaging relative to CT in 13/12/6 and 3/1
patient(s), respectively. Staging results of whole-body MRI
with DWI were equal to those of CT in 62.5% (60/96),
higher in 32.3% (31/96), and lower in 5.2% (5/96) of
patients, with correct/incorrect/unresolved overstaging and
incorrect/unresolved understaging relative to CT in 18/10/3
and 4/1 patient(s), respectively.
Conclusion: Staging of newly diagnosed lymphoma using
whole-body MRI (without and with DWI) equals staging
using CT in the majority of patients. Disagreements between
whole-body MRI and CT are mostly caused by overstaging of
the former relative to the latter, with the number of correctly
and incorrectly overstaged cases being approximately equal.
The potential advantage of DWI is still unproven.
Materials and methods: One hundred and one consecutive
patients with newly diagnosed lymphoma prospectively
underwent whole-body MRI (T1-weighted and T2-weighted
short inversion time inversion recovery [n=101], and DWI
[n=96]) and CT. Ann Arbor stages were assigned according
to whole-body MRI and CT findings. Disagreements in
staging between whole-body MRI (without and with DWI)
and CT were resolved using bone marrow biopsy, 18F-fluoro-
2-deoxyglucose positron emission tomography (FDG-PET),
and follow-up FDG-PET, CT, and whole-body MRI studies as
reference standard.
Results: Staging results of whole-body MRI without DWI
were equal to those of CT in 65.4% (66/101), higher in
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