programma & abstracts - Nederlandse Vereniging voor Radiologie

9 programma abstracts & abstracts
Sessie 9
Neuro- en Hoofdhals radiologie
Vrijdag 30 september, 10.45 - 12.15 uur
O9.1
ARTERIAL CALCIFICATION IN RELATION
TO COGNITION AND STRUCTURAL BRAIN
CHANGES
D. Bos, M.W. Vernooij, S.E. Elias-Smale, G.P. Krestin,
A. Hofman, W.J. Niessen, J.C.M. Witteman, A. van der Lugt,
M.A. Ikram
Erasmus Medisch Centrum, Rotterdam
Purpose: Atherosclerosis plays an important role in the
pathogenesis of cognitive decline and dementia. Calcified
plaque measured with CT is a marker of atherosclerosis.
This study investigates associations between CT-measured
arterial calcifications measured at four locations, with cognition
and macro- and microstructural brain changes.
Method and materials: From the general population, 2437
participants underwent CT of the coronary arteries, aortic
arch, extracranial and intracranial carotid arteries to quantify
calcification volume. Cognitive function was assessed in the
following domains: memory, executive function, information
processing speed and motor speed. In a random subgroup of
844 participants brain MRI was performed to obtain measures
of brain atrophy. Automated quantification of brain MRI
scans yielded tissue-specific brain volumes. Furthermore,
microstructural integrity of white matter was quantified
using diffusion tensor imaging (DTI). Associations between
arterial calcification and cognition, brain tissue volumes and
DTI-measures were assessed with linear regression, adjusted
for relevant confounders.
Results: Larger calcification load was associated with
worse cognitive scores in all domains. Calcification in all
vessel beds was also associated with smaller total brain
volume. Specifically, coronary calcification was associated
with smaller grey matter volume, whilst both extra- and
intracranial carotid artery calcification was associated with
smaller white matter volume. Calcification in all vessel beds
was associated with worse microstructural integrity of white
matter.
Conclusion: Arterial calcification load is associated with
worse cognitive performance. Moreover, larger calcification
load is associated with smaller brain tissue volumes and
with worse white matter microstructural quality, elucidating
possible mechanisms through which atherosclerosis leads to
poorer cognition.
O9.2
TIA AND STROKE PATIENTS WITH CAROTID
STENOSIS: PRESENCE OF COMPLICATED
PLAQUE FEATURES AT MRI IS ASSOCIATED
WITH RECURRENT EVENTS
R.M. Kwee 1 , R.J. van Oostenbrugge 1 , W.H. Mess 1 ,
M.H. Prins 1 , R.J. van der Geest 2 , J.W.M. ter Berg 3 ,
C.L. Franke 4 , A.G.G.C. Korten 5 , B.J. Meems 6 ,
J.M.A. van Engelshoven 1 , J.E. Wildberger 1 , M.E. Kooi 1
1
Maastricht Universitair Medisch Centrum, Maastricht
2
Leids Universitair Medisch Centrum, Leiden
3
Orbis Medisch Centrum, Sittard
4
Atrium Medisch Centrum Parkstad, Heerlen
5
Laurentius Ziekenhuis, Roermond
6
VieCuri Medisch Centrum, Venlo
Purpose: There is a need for improved risk stratification of
TIA and stroke patients with carotid atherosclerosis. The
purpose of the present study was to prospectively investigate
whether certain MRI-based carotid plaque characteristics
are associated with recurrent ischemic events.
Materials and Methods: One hundred TIA/stroke patients
with ipsilateral 30-69% carotid stenosis underwent multisequence
MRI, including contrast-enhanced images, of the
carotid plaque within 32.7±19.9 days after the initial event.
For each plaque, vessel wall volume and volumes of lipidrich
necrotic core (LRNC), calcifications, and fibrous tissue
were assessed. Maximum vessel wall thickness, minimum
lumen area, fibrous cap status, and intraplaque hemorrhage
(IPH) were also assessed. Patients were followed by structured
interviews and chart review to determine the recurrence
of ipsilateral TIA and/or ischemic stroke within one year.
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