Principles of cell signaling - UT Southwestern

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39057_ch14_cellbio.qxd 8/28/06 5:11 PM Page 638 Lin, C. and Shalitin, D., 2003. Cryptochrome structure and signal transduction. Annu. Rev. Plant Biol. v. 54 p. 469–496. Rockwell, N.C., Su, Y.-S., and Lagarias, J.C., 2006. Phytochrome structure and signaling mechanisms. Annu. Rev. Plant Biology, v. 57 p. 837–858. Sancar, A., 2000. Cryptochrome: the second photoactive pigment in the eye and its role in circadian photoreception. Annu. Rev. Biochem. v. 69 p. 31–67. 14.3 Receptors sense diverse stimuli but initiate a limited repertoire of cellular signals Research Klein, C., Paul, J. I., Sauvé, K., Schmidt, M. M., Arcangeli, L., Ransom, J., Trueheart, J., Manfredi, J. P., Broach, J. R., and Murphy, A. J., 1998. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nat. Biotechnol. v. 16 p. 1334–1337. 14.5 Ligand binding changes receptor conformation Review Ross, E. M., and Kenakin, T. P., 2001. Pharmacodynamics: Mechanisms of drug action and the relationship between drug concentration and effects. In Goodman and Gilmans’s The Pharmacological Basis of Therapeutics, 10th. Ed., J. G. Hardman and L. E. Limbird, eds., New York: McGraw- Hill, p. 31–43. 14.6 Signals are sorted and integrated in signaling pathways and networks Research Itzkovitz, S., Milo, R., Kashtan, N., Ziv, G., and Alon, U., 2003. Subgraphs in random networks. Phys. Rev. E. v. 68 p. 126–127. 14.7 Cellular signaling pathways can be thought of as biochemical logic circuits Review Milo, R., Shen-Orr, S., Itzkovitz, S., Kashtan, N., Chklovskii, D., and Alon, U., 2002. Network motifs: Simple building blocks of complex networks. Science v. 298 p. 824–827. Research Torres, E. and Rosen, M. K., 2003. Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP. Mol. Cell v. 11 p. 1215–1227. 14.8 Scaffolds increase signaling efficiency and enhance spatial organization of signaling Review Elion, E. A., 2001. The Ste5p scaffold. J. Cell Sci. v. 114 p. 3967–3978. Kholodenko, B. N., 2003. Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors. J. Exp. Biol. v. 206 p. 2073–2082. O’Rourke, S. M., Herskowitz, I., and O’Shea, E. K., 2002. Yeast go the whole HOG for the hyperosmotic response. Trends Genet. v. 18 p. 405–412. Pawson, T. and Nash, P., 2003. Assembly of cell regulatory systems through protein interaction domains. Science v. 300 p. 445–452. Tsunoda, S. and Zuker, C. S., 1999. The organization of INAD-signaling complexes by a multivalent PDZ domain protein in Drosophila photoreceptor cells ensures sensitivity and speed of signaling. Cell Calcium v. 26 p. 165–171. Research Levchenko, A., Bruck, J., and Sternberg, P. W., 2000. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc. Natl. Acad. Sci. USA v. 97 p. 5818–5823. Rensland, H., Lautwein, A., Wittinghofer, A., and Goody, R. S., 1991. Is there a ratelimiting step before GTP cleavage by H- ras p21? Biochemistry v. 30 p. 11181– 11185. Shenker, A., Goldsmith, P., Unson, C. G., and Spiegel, A. M., 1991. The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family. J. Biol. Chem. v. 266 p. 9309– 9313. 14.9 Independent, modular domains specify protein-protein interactions Review Pawson, T. and Nash, P., 2003. Assembly of cell regulatory systems through protein interaction domains. Science v. 300 p. 445–452. Turk, B. E. and Cantley, L. C., 2003. Peptide libraries: at the crossroads of proteomics and bioinformatics. Curr. Opin. Chem. Biol. v. 7 p. 84–90. Research Ginty, D. D., Kornhauser, J. M., Thompson, M. A., Bading, H., Mayo, K. E., Takahashi, J. S., and Greenberg, M. E., 1993. Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science v. 260 p. 238–241. 638 CHAPTER 14 Principles of cell signaling
39057_ch14_cellbio.qxd 8/28/06 5:11 PM Page 639 14.10 Cellular signaling is remarkably adaptive Review Perkins, J. P., Hausdorff, W. P., and Lefkowitz, R. J., 1990. Mechanisms of ligand-induced desensitization of -adrenergic receptors. In The Beta-Adrenergic Receptors, J. P. Perkins, ed., Clifton, NJ: Humana Press, p. 73–124. 14.11 Signaling proteins are frequently expressed as multiple species Review Barnes, N. M., and Sharp, T., 1999. A review of central 5-HT receptors and their function. Neuropharmacology v. 38 p. 1083– 1152. Gilman, A. G., 1987. G proteins: transducers of receptor-generated signals Annu. Rev. Biochem. v. 56 p. 615–649. Rebecchi, M. J., and Pentyala, S. N., 2000. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. v. 80 p. 1291–1335. Sunahara, R. K. and Taussig, R., 2002. Isoforms of mammalian adenylyl cyclase: Multiplicities of signaling. Mol. Interventions v. 2 p. 168–184. 14.14 Second messengers provide readily diffusible pathways for information transfer Review Beavo, J. A., Bechtel, P. J., and Krebs, E. G., 1975. Mechanisms of control for cAMPdependent protein kinase from skeletal muscle. Adv. Cyclic Nucleotide Res. v. 5 p. 241–251. Kobe, B., Heierhorst, J., and Kemp, B. E., 1997. Intrasteric regulation of protein kinases. Adv. Second Messenger Phosphoprotein Res. v. 31 p. 29–40. Wong, W. and Scott, J. D., 2004. AKAP signalling complexes: focal points in space and time. Nat. Rev. Mol. Cell Biol. v. 5 p. 959–970. Research Rall, T. W. and Sutherland, E. W., 1958. Formation of a cyclic adenine ribonucleotide by tissue particles. J. Biol. Chem. v. 232 p. 1065–1076. 14.15 Ca2+ signaling serves diverse purposes in all eukaryotic cells Review Newton, A. C., 2001. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem. Rev. v. 101 p. 2353–2364. Research Clapperton, J. A., Martin, S. R., Smerdon, S. J., Gamblin, S. J., and Bayley, P. M., 2002. Structure of the complex of calmodulin with the target sequence of calmodulin dependent protein kinase I: Studies of the kinase activation mechanism. Biochemistry. v. 41 p. 14669–14679. Kuboniwa, H., Tjandra, N., Grzesiek, S., Ren, H., Klee, C.B., Bax, A., 1995. Solution structure of calcium-free calmodulin. Nat. Struct. Biol. v. 2 p. 768–776. 14.16 Lipids and lipid-derived compounds are signaling molecules Review Rebecchi, M. J., and Pentyala, S. N., 2000. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. v. 80 p. 1291–1335. Yang, C. and Kazanietz, M. G., 2003. Divergence and complexities in DAG signaling: looking beyond PKC. Trends Pharmacol. Sci. v. 24 p. 602–608. 14.17 PI 3-kinase synthesizes a lipid activator of cell motion and shape change Review Downward, J., 2004. PI 3-kinase, Akt and cell survival. Semin. Cell Dev. Biol. v. 15 p. 177–182. Lawlor, M. A. and Alessi, D. R., 2001. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J. Cell Sci. v. 114 p. 2903–2910. Van Haastert, P. J. and Devreotes, P. N. 2004. Chemotaxis: signaling the way forward. Nat. Rev. Mol. Cell Biol. v. 5. p. 626–634. 14.18 Signaling through ion channel receptors is very fast Review Clapham, D. E., 2003. TRP channels as cellular sensors. Nature v. 426 p. 517–524. Corey, D. P., 2003. New TRP channels in hearing and mechanosensation. Neuron v. 39 p. 585–588. Hille, B, 1992. Ionic channels of excitable membranes. Sinauer Associates. Siegelbaum, S. A. and Koester, J., 2000. Ion channels and Membrane potential, in Principles of Neural Science, 4th. Ed., E. R. Kandel, J. H. Schwartz, and T. M. Jessell, eds., New York: McGraw-Hill. p. 105–139. Research Unwin, N., 2005. Refined structure of the nicotinic acetylcholine receptor at 4Å resolution. J. Mol. Biol. v. 346 p. 967. 14.19 Nuclear receptors regulate transcription References 639
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