Biostatistics

394 CHAPTER 8 ANALYSIS OF VARIANCE
Normal Lateral Medial Multidirectional
8 4 12 16 10 15
16 18 8 25 5 26
22 5 8 20 10 8
26 6 20 8 12 12
8 32 5 8 14 40
12 30 10 14 20
8 10 18 16
12 28 4 34
20 6 20 14
20 9 20 6
5 10 20 35
10 20 22 24
4 9 15 25
2 10 10 10
6 12 5 16
7 0 5 30
0 35 6 30
2 1 15
15 5 25
5 22 10
22 20
Source: Data provided courtesy of Dr. Robert A. Teitge.
46. A study by Ikeda et al. (A-49) was designed to determine the dose of ipratropium bromide aerosol
that improves exercise performance using progressive cycle ergometry in patients with stable chronic
obstructive pulmonary disease. The mean age of the 20 male subjects was 69.2 years with a standard
deviation of 4.6 years. Among the data collected were the following maximum ventilation
VE max; L=min values at maximum achieved exercise for different ipratropium bromide dosage
levels ðmgÞ:
Placebo 40 80 160 240
26 24 23 25 28
38 39 43 43 37
49 46 54 57 52
37 39 39 38 38
34 33 37 37 41
42 38 44 44 42
23 26 28 27 22
38 41 44 37 40
37 37 36 38 39
33 35 34 38 36
40 37 40 46 40
52 58 48 58 63
45 48 47 51 38
(Continued)