Biostatistics

742 CHAPTER 13 NONPARAMETRIC AND DISTRIBUTION-FREE STATISTICS
Group PRE POST Group PRE POST
Patient 4.88 70.20 Patient 36.80 142.45
Patient 42.75 86.25
Source: Data provided courtesy of Dr. Khashayar Sakhaee.
21. The purpose of a study by Dubuis et al. (A-23) was to determine whether neuropsychological deficit
of children with the severe form of congenital hypothyroidism can be avoided by earlier onset of
therapy and higher doses of levothyroxine. Subjects consisted of 10 infants (ages 3 to 24 days) with
severe and 35 infants (ages 2 to 10 days) with moderate congenital hypothyroidism. Among the data
collected were the following measurements on plasma T 4 (nmol/L) levels at screening:
Severe Cases
Moderate Cases
Sex
T 4
(nmol/L)
Sex
T 4
(nmol/L)
Sex
T 4
(nmol/L)
M 16 F 20 F 62
M 57 F 34 M 50
M 40 F 188 F 40
F 50 F 69 F 116
F 57 F 162 F 80
F 38 F 148 F 97
F 51 F 108 F 51
F 38 F 54 F 84
M
F 96 F 51
F 60 M 76 F 94
M 122 M 158
M 43 F
F 40 M 47
F 29 M 143
F 83 M 128
F 62 M 112
M 111
F 84
M 55
¼ Missing data.
Source: Data provided courtesy
of Dr. Guy Van Vliet.
22. Kuna et al. (A-24) conducted a study concerned with chemokines in seasonal allergic rhinitis.
Subjects included 18 atopic individuals with seasonal allergic rhinitis caused by ragweed pollen.
Among the data collected on these subjects were the following eosinophil cationic protein (ECP) and
histamine measurements:
ECP (ng/ml) Histamine (ng/ml) ECP (ng/ml) Histamine (ng/ml)
511.0 31.2 25.3 5.6
388.0 106.0 31.1 62.7
14.1 37.0 325.0 138.0
314.0 90.0 437.0 116.0
(Continued)