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590 CHAPTER 11 REGRESSION ANALYSIS: SOME ADDITIONAL TECHNIQUES 24. According to Fils-Aime et al. (A-21), epidemiologic surveys have found that alcoholism is the most common mental or substance abuse disorder among men in the United States. Fils-Aime and associates investigated the interrelationships of age at onset of excessive alcohol consumption, family history of alcoholism, psychiatric comorbidity, and cerebrospinal fluid (CSF) monoamine metabolite concentrations in abstinent, treatment-seeking alcoholics. Subjects were mostly white males classified as experiencing early (25 years or younger) or late (older than 25 years) onset of excessive alcohol consumption. Among the data collected were the following measurements on CSF tryptophan (TRYPT) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations (pmol/ml). 5-HIAA TRYPT Onset 1 ¼ Early 0 ¼ Late 5-HIAA TRYPT Onset 1 ¼ Early 0 ¼ Late 57 3315 1 102 3181 1 116 2599 0 51 2513 1 81 3334 1 92 2764 1 78 2505 0 104 3098 1 206 3269 0 50 2900 1 64 3543 1 93 4125 1 123 3374 0 146 6081 1 147 2345 1 96 2972 1 102 2855 1 112 3962 0 93 2972 1 23 4894 1 128 3904 0 109 3543 1 69 2564 1 80 2622 1 20 8832 1 111 3012 1 66 4894 0 85 2685 1 90 6017 1 131 3059 0 103 3143 0 58 3946 1 68 3729 0 110 3356 0 81 3150 1 80 3671 1 143 3955 1 42 4155 1 121 4288 1 80 1923 1 149 3404 0 91 3589 1 82 2547 1 102 3839 0 100 3633 1 93 2627 0 117 3309 1 98 3181 0 41 3315 1 78 4428 0 223 3418 0 152 3303 0 96 2295 1 108 5386 1 87 3232 0 102 3282 1 96 3496 1 122 2754 1 34 2656 1 81 4321 1 98 4318 1 81 3386 1 86 3510 0 99 3344 1 118 3613 1 73 3789 1 84 3117 1 163 2131 1 99 3496 1 109 3030 0 114 4612 1 90 4731 1 (Continued )
REVIEW QUESTIONS AND EXERCISES 591 5-HIAA TRYPT Onset 1 ¼ Early 0 ¼ Late 5-HIAA TRYPT Onset 1 ¼ Early 0 ¼ Late 140 3051 1 110 4581 1 74 3067 1 48 3292 0 45 2782 1 77 4494 0 51 5034 1 67 3453 1 99 2564 1 92 3373 1 54 4335 1 86 3787 0 93 2596 1 101 3842 1 50 2960 1 88 2882 1 118 3916 0 38 2949 1 96 2797 0 75 2248 0 49 3699 1 35 3203 0 133 2394 0 53 3248 1 105 2495 0 77 3455 0 61 2496 1 179 4521 1 197 2123 1 151 3240 1 87 3320 0 57 3905 1 50 3117 1 45 3642 1 109 3308 0 76 5233 0 59 3280 1 46 4150 1 107 3151 1 98 2579 1 85 3955 0 84 3249 1 156 3126 0 119 3381 0 110 2913 0 41 4020 1 81 3786 1 40 4569 1 53 3616 1 149 3781 1 64 3277 1 116 2346 1 57 2656 1 76 3901 1 29 4953 0 96 3822 1 34 4340 1 Source: Data provided courtesy of Dr. Markku Linnoila. 25. The objective of a study by Abrahamsson et al. (A-22) was to investigate the anti-thrombotic effects of an inhibitor of the plasminogen activator inhibitor-1 (PAI-1) in rats given endotoxin. Experimental subjects were male Sprague–Dawley rats weighing between 300 and 400 grams. Among the data collected were the following measurements on PAI-1 activity and the lung 125 I-concentration in anesthetized rats given three drugs: Drugs Plasma PAI-1 Activity (U/ml) 125 I-Fibrin in the Lungs (% of Ref. Sample) Endotoxin 127 158 175 154 161 118 137 77 219 172 (Continued )
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TENTH EDITION BIOSTATISTICS A Found
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VP & EXECUTIVE PUBLISHER: ACQUISITI
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PREFACE This 10th edition of Biosta
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PREFACE ix SUPPLEMENTS Instructor
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BRIEF CONTENTS 1 INTRODUCTION TO BI
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xiv CONTENTS 6.3 The t Distribution
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CHAPTER1 INTRODUCTION TO BIOSTATIST
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1.2 SOME BASIC CONCEPTS 3 Sources o
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1.3 MEASUREMENT AND MEASUREMENT SCA
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1.4 SAMPLING AND STATISTICAL INFERE
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1.5 THE SCIENTIFIC METHOD AND THE D
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1.6 COMPUTERS AND BIOSTATISTICAL AN
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REVIEW QUESTIONS AND EXERCISES 17 a
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CHAPTER2 DESCRIPTIVE STATISTICS CHA
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2.2 THE ORDERED ARRAY 21 TABLE 2.2.
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2.3 GROUPED DATA: THE FREQUENCY DIS
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EXERCISES 31 3 ¼ an abundance of s
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EXERCISES 33 25.21 30.49 27.38 36.4
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EXERCISES 35 2.3.7 In a study of ph
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EXERCISES 37 0.6870 0.6900 0.6910 0
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2.4 DESCRIPTIVE STATISTICS: MEASURE
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EXERCISES 53 2.5.1 Porcellini et al
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SUMMARY OF FORMULAS FOR CHAPTER 2 5
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REVIEW QUESTIONS AND EXERCISES 57 R
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REVIEW QUESTIONS AND EXERCISES 59 1
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REFERENCES 63 DRINK TOUNCES TGRAMS
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CHAPTER3 SOME BASIC PROBABILITY CON
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3.2 TWO VIEWS OF PROBABILITY: OBJEC
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3.4 CALCULATING THE PROBABILITY OF
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EXERCISES 77 (d) If we pick a subje
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3.5 BAYES’ THEOREM, SCREENING TES
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3.5 BAYES’ THEOREM, SCREENING TES
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EXERCISES 83 EXERCISES 3.5.1 A medi
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REVIEW QUESTIONS AND EXERCISES 87 (
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REVIEW QUESTIONS AND EXERCISES 89 i
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REFERENCES 91 Applications Referenc
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4.2 PROBABILITY DISTRIBUTIONS OF DI
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4.3 THE BINOMIAL DISTRIBUTION 99 TA
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4.3 THE BINOMIAL DISTRIBUTION 101 E
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4.3 THE BINOMIAL DISTRIBUTION 103 f
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EXAMPLE 4.3.4 According to a June 2
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EXERCISES 107 Data: C1: 0 1 2 3 4 5
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4.4 THE POISSON DISTRIBUTION 109 pr
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4.4 THE POISSON DISTRIBUTION 111 or
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4.5 CONTINUOUS PROBABILITY DISTRIBU
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4.5 CONTINUOUS PROBABILITY DISTRIBU
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4.6 THE NORMAL DISTRIBUTION 117 .68
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4.6 THE NORMAL DISTRIBUTION 119 σ
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4.6 THE NORMAL DISTRIBUTION 121 _ 2
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4.7 NORMAL DISTRIBUTION APPLICATION
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TableD,wefindthattheareatotheleftof
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EXERCISES 127 Data: C1:-3-2-10123 D
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SUMMARY OF FORMULAS FOR CHAPTER 4 S
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REVIEW QUESTIONS AND EXERCISES 131
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REFERENCES 133 REFERENCES Methodolo
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5.2 SAMPLING DISTRIBUTIONS 135 voca
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5.3 DISTRIBUTION OF THE SAMPLE MEAN
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5.4 DISTRIBUTION OF THE DIFFERENCE
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EXERCISES 149 FIGURE 5.4.2 Sampling
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5.5 DISTRIBUTION OF THE SAMPLE PROP
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EXERCISES 153 51 percent had adequa
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CHAPTER6 ESTIMATION CHAPTER OVERVIE
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6.1 INTRODUCTION 163 We will find t
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6.2 CONFIDENCE INTERVAL FOR A POPUL
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6.3 THE t DISTRIBUTION 171 someone
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6.3 THE t DISTRIBUTION 173 Normal d
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EXERCISES 175 Yes Population normal
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6.4 CONFIDENCE INTERVAL FOR THE DIF
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EXERCISES 183 EXERCISES R Code: > t
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6.7 DETERMINATION OF SAMPLE SIZE FO
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6.8 DETERMINATION OF SAMPLE SIZE FO
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6.9 CONFIDENCE INTERVAL FOR THE VAR
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6.9 CONFIDENCE INTERVAL FOR THE VAR
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EXERCISES 197 x 2 1 ða=2Þ ¼ 14:4
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6.10 CONFIDENCE INTERVAL FOR THE RA
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6.10 CONFIDENCE INTERVAL FOR THE RA
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REFERENCES 211 3. W. V. BEHRENS,
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REFERENCES 213 A-30. ELENI KOUSTA,
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7.1 INTRODUCTION 215 7.1 INTRODUCTI
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7.1 INTRODUCTION 217 question: Can
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7.1 INTRODUCTION 219 DEFINITION The
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7.1 INTRODUCTION 221 Evaluate data
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7.2 HYPOTHESIS TESTING: A SINGLE PO
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EXERCISES 233 Dialog box: Session c
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EXERCISES 235 7.2.10 Following a we
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7.3 HYPOTHESIS TESTING: THE DIFFERE
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EXAMPLE 7.3.2 The purpose of a stud
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EXERCISES 245 The SAS System The TT
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EXERCISES 247 Primary Hypertensive
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7.4 PAIRED COMPARISONS 249 7.3.10 R
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7.4 PAIRED COMPARISONS 251 where d
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7.4 PAIRED COMPARISONS 253 a = .05
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EXERCISES 255 7.4.1 Ellen Davis Jon
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EXERCISES 263 MINITAB Output Test a
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7.8 HYPOTHESIS TESTING: THE RATIO O
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7.8 HYPOTHESIS TESTING: THE RATIO O
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EXERCISES 271 EXERCISES In the foll
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7.9 THE TYPE II ERROR AND THE POWER
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7.9 THE TYPE II ERROR AND THE POWER
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7.10 DETERMINING SAMPLE SIZE TO CON
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EXERCISES 279 We set the right-hand
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REFERENCES 301 A-17. JOHN S. MORLEY
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REFERENCES 303 A-56. LUIGI BENINI,
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8.1 INTRODUCTION 305 8.1 INTRODUCTI
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8.1 INTRODUCTION 307 who received d
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8.2 THE COMPLETELY RANDOMIZED DESIG
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Dependent Variable: Selenium Tukey
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EXERCISES 329 Elbow Angle (Degrees)
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EXERCISES 331 Age Groups (Years) Ag
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EXERCISES 333 Group 1 Group 2 Group
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Objective The objective in using th
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8.3 THE RANDOMIZED COMPLETE BLOCK D
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EXERCISES 343 The SAS System Analys
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EXERCISES 345 group were randomly a
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8.4 THE REPEATED MEASURES DESIGN 34
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EXERCISES 357 Is there sufficient e
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8.5 THE FACTORIAL EXPERIMENT 359 In
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8.5 THE FACTORIAL EXPERIMENT 361 In
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8.5 THE FACTORIAL EXPERIMENT 363 Be
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8.5 THE FACTORIAL EXPERIMENT 365 TA
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8.5 THE FACTORIAL EXPERIMENT 367 Ro
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EXERCISES 369 The SAS System Analys
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EXERCISES 371 Physical Psychiatric
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8.6 SUMMARY 373 Percent Change in C
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REFERENCES 409 Applications Referen
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REFERENCES 411 Postmenopausal Women
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CHAPTER9 SIMPLE LINEAR REGRESSION A
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9.2 THE REGRESSION MODEL 415 some e
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9.3 THE SAMPLE REGRESSION EQUATION
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EXERCISES EXERCISES 423 The Least-S
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EXERCISES 425 CoaguChek Hospital Co
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9.4 EVALUATING THE REGRESSION EQUAT
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9.5 USING THE REGRESSION EQUATION I
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9.5 USING THE REGRESSION EQUATION 4
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9.6 THE CORRELATION MODEL 445 9.6 T
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9.7 THE CORRELATION COEFFICIENT 447
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EXERCISES 455 is employed. We first
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EXERCISES 457 9.7.3 In the study by
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9.8 SOME PRECAUTIONS 459 X Y X Y 5.
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9.9 SUMMARY 461 variance, which tes
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9.7.3 t statistic for correlation c
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REFERENCES 487 A-4. ROBERT B. PARKE
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CHAPTER10 MULTIPLE REGRESSION AND C
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Assumptions follows. 10.2 THE MULTI
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10.3 OBTAINING THE MULTIPLE REGRESS
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10.3 OBTAINING THE MULTIPLE REGRESS
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EXERCISES 497 EXERCISES Obtain the
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EXERCISES 499 10.3.3 In a study of
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10.4 EVALUATING THE MULTIPLE REGRES
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10.5 USING THE MULTIPLE REGRESSION
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EXERCISES 509 and has an education
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10.6 THE MULTIPLE CORRELATION MODEL
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This equation may be used for estim
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EXERCISES 521 HIV DNA Blood (Y) HIV
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SUMMARY OF FORMULAS FOR CHAPTER 10
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10.6.7 t statistic for testing hypo
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REFERENCES 537 4. Refer to the data
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12.7 RELATIVE RISK, ODDS RATIO, AND
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EXERCISES 653 Smoking_status * Obse
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12.8 SUMMARY 655 collected data on
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REFERENCES 667 12. R. LATSCHA, “T
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REFERENCES 669 A-35. CRAIG R. COHEN
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13.1 INTRODUCTION 671 2. be able to
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13.3 THE SIGN TEST 673 13.3 THE SIG
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13.3 THE SIGN TEST 675 TABLE 13.3.2
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13.3 THE SIGN TEST 677 EXAMPLE 13.3
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13.3 THE SIGN TEST 679 one sample i
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13.4 THE WILCOXON SIGNED-RANK TEST
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13.4 THE WILCOXON SIGNED-RANK TEST
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13.5 THE MEDIAN TEST 687 TABLE 13.5
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EXAMPLE 13.6.1 A researcher designe
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13.6 THE MANN-WHITNEY TEST 693 to t
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13.6 THE MANN-WHITNEY TEST 695 Dial
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EXERCISES 697 deficit in Sprague-Da
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Assumptions the following: 1. The s
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13.7 THE KOLMOGOROV-SMIRNOV GOODNES
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EXERCISES 703 1.0 .9 Cumulative rel
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13.8 THE KRUSKAL-WALLIS ONE-WAY ANA
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13.8 THE KRUSKAL-WALLIS ONE-WAY ANA
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EXERCISES 709 Data: C1: 12.22 28.44
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EXERCISES 711 Improvement (Control)
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13.9 THE FRIEDMAN TWO-WAY ANALYSIS
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13.9 THE FRIEDMAN TWO-WAY ANALYSIS
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EXERCISES 717 Subject Area Student
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13.10 THE SPEARMAN RANK CORRELATION
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EXERCISES 725 Rank by Rank by Area
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13.11 NONPARAMETRIC REGRESSION ANAL
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13.11 NONPARAMETRIC REGRESSION ANAL
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REFERENCES 747 cardiac operations.
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REFERENCES 749 A-14. WENDY GANTT an
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14.2 TIME-TO-EVENT DATA AND CENSORI
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14.3 THE KAPLAN-MEIER PROCEDURE 757
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14.3 THE KAPLAN-MEIER PROCEDURE 759
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EXERCISES 761 1.0 .8 73% Low-grade
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14.4 COMPARING SURVIVAL CURVES 763
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14.4 COMPARING SURVIVAL CURVES 765
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EXERCISES 767 EXERCISES 14.4.1 If a
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14.5 COX REGRESSION: THE PROPORTION
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14.5 COX REGRESSION: THE PROPORTION
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REFERENCES 777 REFERENCES Methodolo
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A-2 APPENDIX STATISTICAL TABLES
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ANSWERS TO ODD-NUMBERED EXERCISES C
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ANSWERS TO ODD-NUMBERED EXERCISES A
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I-2 INDEX Confidence coefficient, 1
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I-4 INDEX Median test, 686-689 MINI
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I-6 INDEX SAS: and chi-square analy
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