Biostatistics

REVIEW QUESTIONS AND EXERCISES 405
Rat
Diet
HW/BW
(g/100 g)
LW/BW
(g/100 g)
KW/BW
(g/100 g)
SW/BW
(g/100 g)
Ceruloplasmin
(mg/dl)
6 0.00249 0.00589 0.00463 0.00126 35.30
7 0.00284 0.00773 0.00550 0.00187 39.00
8 PF 0.00227 0.00788 0.00481 0.00217 28.00
9 0.00254 0.00697 0.00513 0.00189 34.20
10 0.00279 0.00900 0.00514 0.00171 45.20
11 0.00247 0.00919 0.00469 0.00159 34.60
12 0.00254 0.00829 0.00520 0.00144 39.00
13 CuA 0.00280 0.00906 0.00507 0.00169 37.10
14 0.00249 0.00917 0.00491 0.00155 33.40
15 0.00268 0.01191 0.00560 0.00165 37.30
nd, no data.
Source: Data provided courtesy of Corrie B. Allen.
63. Hughes et al. (A-66) point out that systemic complications in acute pancreatitis are largely responsible
for mortality associated with the disease. They note further that proinflammatory cytokines, particularly
TNFa, may play a central role in acute pancreatitis by mediating the systemic sequelae. In their research
they used a bile-infusion model of acute pancreatitis to show amelioration of disease severity as well as
an improvement in overall survival by TNFa inhibition. Experimental material consisted of adult male
Sprague-Dawley rats weighing between 250 and 300 grams divided into three groups: untreated (bile
solution infused without treatment); treated (bile solution infused preceded by treatment with
polyclonal anti TNFa antibody); and sham (saline infused). Among the data collected were the
following hematocrit (%) values for animals surviving more than 48 hours:
Sham Untreated Treated
38 56 40
40 60 42
32 50 38
36 50 46
40 50 36
40 35
38 40
40 40
38 55
40 35
36
40
40
35
45
Source: Data provided courtesy of
Dr. A. Osama Gaber.
64. A study by Smarason et al. (A-67) was motivated by the observations of other researchers that sera
from pre-eclamptic women damaged cultured human endothelial cells. Subjects for the present study
were women with pre-eclampsia, matched control women with normal pregnancies, and nonpregnant