Biosafety Guidelines For Research On Genetically Modified ...

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• take responsibility for drafting rules and making decisions about specific procedural safety matters. GMAC does not need to be consulted about these, as long as they are consistent with these guidelines. 5.2.7 Reporting Requirements When the IBC is being set up it should provide GMAC with a completed ‘Annual Report by Institutional Biosafety Committee’ form. This form can be found in Appendix 3. The deadline for the annual submission is 1st January. 5.2.8 Medical History of Workers For personnel using GM-BSL2 physical containment facilities, GMAC advises that no special arrangements are necessary outside the normal institutional practices for laboratory workers. Many institutions doing microbiological research, routinely take serum samples from personnel at regular intervals. Such samples are stored for diagnostic tests on workers exposed to accidents or who develop unexplained illness. For experiments requiring a physical containment level of GM-BSL3 or higher, laboratory workers should have an initial medical examination, and other requirements as stipulated under the OSH Guidelines. 5.2.9 Accidents and Incidents The IBC or the Biological Safety Officer should record both the accident or incident and the follow-up action. If the IBC Chair is satisfied that the accident or incident was directly attributable to genetic manipulation work, and was significant, they should make a report to both the GMAC and the head of the institution. An example of such an incident could be the intentional failure to comply with these guidelines, or an incident which might have risked human health or the environment. 5.3 PRINCIPAL INVESTIGATORS The Principal Investigator should be thoroughly familiar with the requirements of these guidelines and should ensure that, the guidelines are adhered to, for any project he/she is responsible and for which, involves the use of genetic manipulation. Specifically, he/she should: • assess the proposal to decide if it falls within the guidelines. If unsure, the investigator should consult the IBC; • provide all information on the proposal that the IBC may need for assessment or monitoring of the proposal; • follow through on GMAC's and IBC's advice and recommendations; • fill out a typed original GMAC ‘Proposal Form for Assessment of Genetic Manipulation Work’ and hand a copy (keeping a second copy) to their IBC, before starting work on any project which falls under these Guidelines, and ensure that work does not commence until approval is granted by the IBC; Page 17
• submit a new proposal form to the IBC before any major change is made to the experimental system of a proposal, which may result in a change of category or which may affect the exempt status of Category C projects. • conduct experiments under the conditions of physical containment approved by the IBC or as advised by the GMAC in the case of category A proposals (see Section 4); • ensure that students, subordinates, and other co-workers are aware of the nature of potential hazards of the work and have been given relevant training. They should also arrange for training, if needed; • inform the IBC of any changes to the project team; • promptly report accidents, unexplained illnesses and absences to the IBC; • advise the IBC when intending to import biological material(s) falling within these guidelines (see also Section 6.6). Page 18
Page 1 and 2: THE SINGAPORE BIOSAFETY GUIDELINES
Page 3 and 4: APPENDICES Appendix 1 Other Relevan
Page 5 and 6: 1.4 DEFINITIONS OF ABBREVIATIONS Fo
Page 7 and 8: 2.2 EXEMPTIONS 2.2.1 The following
Page 9 and 10: SECTION 3: SUMMARY OF PROCEDURES 3.
Page 11 and 12: 3.3 CATEGORY A - EXPERIMENTS REQUIR
Page 13 and 14: SECTION 4: EXPERIMENTS COVERED BY T
Page 15 and 16: 4.2 CATEGORY B - EXPERIMENTS REQUIR
Page 17 and 18: SECTION 5: ROLES AND RESPONSIBILITI
Page 19: 5.2.5 Monitoring of Work The IBC sh
Page 23 and 24: • All materials that are genetica
Page 25 and 26: 6.5 SUPPLY OF GENETICALLY MANIPULAT
Page 27 and 28: 6.6.5 The form should contain any r
Page 29 and 30: BLANK PAGE
Page 31 and 32: 3. Worldwide guidelines specific to
Page 33 and 34: xiv. AS 2252.2: 1994: xv. AS 2647:
Page 35 and 36: APPENDIX 2: LIST OF GMAC-APPROVED H
Page 37 and 38: APPENDIX 3: INSTRUCTIONS FOR COMPLE
Page 39 and 40: PROPOSAL FORM FOR ASSESSMENT OF GEN
Page 41 and 42: -----------------------------------
Page 43 and 44: ) Describe the techniques to be emp
Page 45 and 46: ii) Category B iii) Category C C. R
Page 47 and 48: APPENDIX 4: TOXINS For work involvi
Page 49 and 50: 4. Procedures for handling viruses
Page 51 and 52: staff shall handle these infected a
Page 53 and 54: APPENDIX 7: REQUIREMENTS FOR GENETI
Page 55 and 56: equire the provision of a front cov
Page 57 and 58: Signs 10. An automatically-starting
Page 59 and 60: 9. All plants in the plant house sh
Page 61 and 62: APPENDIX 12: PROCEDURES FOR EXPERIM
Page 63 and 64: APPENDIX 13: DESIGN OF ANIMAL FACIL
Page 65 and 66: Other Work Being Performed in the S
Page 67 and 68: permitted in animal rooms. Personne
Page 69 and 70: APPENDIX 15: REQUIREMENTS FOR GENET
Page 71 and 72:
APPENDIX 16: REQUIREMENTS FOR INSEC
Page 73 and 74:
APPENDIX 17: REQUIREMENTS FOR INSEC
Page 75 and 76:
APPENDIX 18: PROCEDURES FOR EXPERIM
Page 77 and 78:
From Bio-Security Assurance Arrange
Page 79 and 80:
VIRUSES (con’t) Family and genus
Page 81 and 82:
PESTS (cont’d) INSECTS MAIN HOST
Page 83 and 84:
PESTS (cont’d) NEMATODES MAIN HOS
Page 85 and 86:
PESTS (cont’d) NEMATODES MAIN HOS
Page 87 and 88:
From the Notifiable Diseases List o
Page 89 and 90:
From the Notifiable Diseases List o
Page 91 and 92:
APPENDIX 20: GLOSSARY Note: Words a
Page 93 and 94:
fusion gamete gene gene therapy gen
Page 95 and 96:
polymerase chain reaction prion pro
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