Biosafety Guidelines For Research On Genetically Modified ...

8. Biological safety cabinets are to be used within the GA-BSL3 facility for
containment of aerosols and control of infectious material. The cabinet should
exhaust to the outside air through a HEPA filter or to the room air extract system.
9. Infected animals may be housed in isolators, safety cabinets, or containment units.
Operating Procedures
10. No other work is to be performed simultaneously with work requiring GA-BSL3
containment. The GA-BSL3 facility must be inspected at least annually by the IBC
to ensure that its containment requirements are intact. Only people authorised by
the IBC are to enter the animal facility and they can do so only after they have
been advised of the potential hazards and meet any specific requirements (e.g.,
immunisation). A record should be maintained to provide an up-to-date inventory
of the animals present and a chronological record of procedures performed.
11. The protective clothing and footwear must be removed before leaving the facility.
Dirty clothing must be decontaminated, preferably autoclaved, before being
laundered.
12. Special attention must be paid to containing animals during experiments and to the
prevention of their escape.
13. Live animals must not leave the facility. Animal carcasses must be rendered safe
by sterilisation before disposal. Animals used in genetic manipulation experiments
are not to be used for other purposes or to provide tissue for other purposes.
Appendix - Page 33