Biosafety Guidelines For Research On Genetically Modified ...

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transgenic material before disposal. The proposed treatment procedures and evidence for their efficacy shall be provided to AVA for case-by-case assessment. • Since many fish species have sticky eggs which attach firmly to substrates, nets and other equipment used in the tank during spawning shall be sterilised after use. If fish are induced to spawn on the sides of tanks, the tanks shall be decontaminated after use by a procedure of demonstrable efficacy in sterilising eggs and sperm for the species used. Work with infectious recombinant microorganisms in aquatic organisms • General practices shall be as required for GM-BSL2 or GM-BSL3 laboratory work depending on the microorganism. • To prevent escape of adult aquatic organisms into the sewerage system, a grill or mesh, with an appropriate grid size to prevent passage of adults of the species being used, shall be fitted to outlets used for disposal of tank water. • Tank water used for work with infectious recombinant microorganisms, or tank water that has any potential to contain embryos, sperm, eggs or larvae of infected aquatic organisms, shall be treated to ensure inactivation of viable material before disposal. The proposed treatment procedures shall be provided to AVA for case-by-case assessment. Appendix - Page 39
From Bio-Security Assurance Arrangement <strong>Guidelines</strong> APPENDIX 19: REGULATED ORGANISMS Please note that all organisms under CDC Risk Group 4 are strictly prohibited. Organisms under CDC Risk Group 3 (as listed below * ) requires special permission from the relevant authorities. BACTERIA, CHLAMYDIA, RICKETTSIAE AND MYCOPLASMA Bacillus anthracis Brucella spp Franciscella tularensis Mycoplasma agalactiae Mycoplasma mycoides var mycoides (contagious bovine pleuropneumonia) Pseudomonas mallei (Glanders) Rickettsia ruminatium (Heart water) PARASITES Babesia equi (Equine piroplasmosis) Babesia caballi (Equine piroplasmosis) Chrysomia bezziana (Screw-worm fly) Ehrlichia sp (Potomac fever) Psoroptes ovis (Sheep scab) Theileria parva sp (East coast fever) Trichinella spiralis (Trichinosis) Trypanosoma evansi (Surra) Trypanosoma equiperdum (Dourine) VIRUSES Family and genus Arteriviridae Bunyaviridae Bunyavirus Nairovirus Phlebovirus Regulated species Equine viral arteritis Porcine reproductive respiratory syndrome Cache Valley Nairobi sheep disease Rift Valley fever Caliciviridae Calicivirus Circoviridae Circovirus Coronaviridae Coronavirus Vesicular exanthema Chicken anaemia Transmissible gastro -enteritis * This list is not exhaustive. Importation of other animal disease organisms may be prohibited. An additional list of prohibited organisms from the Bio-Security Assurance Arrangement (published by AVA) and the Notifiable Diseases list of the Animal and Birds Act are included in this Appendix. The Agri-food and Veterinary Authority should be consulted for updates to the following lists of prohibited organisms from the Bio-Security Assurance Arrangement <strong>Guidelines</strong> of the Agri-food and Veterinary Authority and the Notifiable Diseases list of the Animal and Birds Act. Appendix - Page 40
Page 1 and 2:
THE SINGAPORE BIOSAFETY GUIDELINES
Page 3 and 4:
APPENDICES Appendix 1 Other Relevan
Page 5 and 6:
1.4 DEFINITIONS OF ABBREVIATIONS Fo
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2.2 EXEMPTIONS 2.2.1 The following
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SECTION 3: SUMMARY OF PROCEDURES 3.
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3.3 CATEGORY A - EXPERIMENTS REQUIR
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SECTION 4: EXPERIMENTS COVERED BY T
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4.2 CATEGORY B - EXPERIMENTS REQUIR
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SECTION 5: ROLES AND RESPONSIBILITI
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5.2.5 Monitoring of Work The IBC sh
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• submit a new proposal form to t
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• All materials that are genetica
Page 25 and 26: 6.5 SUPPLY OF GENETICALLY MANIPULAT
Page 27 and 28: 6.6.5 The form should contain any r
Page 29 and 30: BLANK PAGE
Page 31 and 32: 3. Worldwide guidelines specific to
Page 33 and 34: xiv. AS 2252.2: 1994: xv. AS 2647:
Page 35 and 36: APPENDIX 2: LIST OF GMAC-APPROVED H
Page 37 and 38: APPENDIX 3: INSTRUCTIONS FOR COMPLE
Page 39 and 40: PROPOSAL FORM FOR ASSESSMENT OF GEN
Page 41 and 42: -----------------------------------
Page 43 and 44: ) Describe the techniques to be emp
Page 45 and 46: ii) Category B iii) Category C C. R
Page 47 and 48: APPENDIX 4: TOXINS For work involvi
Page 49 and 50: 4. Procedures for handling viruses
Page 51 and 52: staff shall handle these infected a
Page 53 and 54: APPENDIX 7: REQUIREMENTS FOR GENETI
Page 55 and 56: equire the provision of a front cov
Page 57 and 58: Signs 10. An automatically-starting
Page 59 and 60: 9. All plants in the plant house sh
Page 61 and 62: APPENDIX 12: PROCEDURES FOR EXPERIM
Page 63 and 64: APPENDIX 13: DESIGN OF ANIMAL FACIL
Page 65 and 66: Other Work Being Performed in the S
Page 67 and 68: permitted in animal rooms. Personne
Page 69 and 70: APPENDIX 15: REQUIREMENTS FOR GENET
Page 71 and 72: APPENDIX 16: REQUIREMENTS FOR INSEC
Page 73 and 74: APPENDIX 17: REQUIREMENTS FOR INSEC
Page 75: APPENDIX 18: PROCEDURES FOR EXPERIM
Page 79 and 80: VIRUSES (con’t) Family and genus
Page 81 and 82: PESTS (cont’d) INSECTS MAIN HOST
Page 83 and 84: PESTS (cont’d) NEMATODES MAIN HOS
Page 85 and 86: PESTS (cont’d) NEMATODES MAIN HOS
Page 87 and 88: From the Notifiable Diseases List o
Page 89 and 90: From the Notifiable Diseases List o
Page 91 and 92: APPENDIX 20: GLOSSARY Note: Words a
Page 93 and 94: fusion gamete gene gene therapy gen
Page 95 and 96: polymerase chain reaction prion pro
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