Biosafety Guidelines For Research On Genetically Modified ...

More documents

Recommendations

Info

6.2.2 The IBC may formulate whatever rules it considers essential to meet these conditions. It may be necessary for the IBC to inspect the transport arrangements to determine that the above principles are complied with and that any additional conditions which the IBC considers appropriate have been met (see also Appendix 13). 6.2.3 Animal boxes should comply with IATA standards. Modifications can be made to the boxes especially for pathogen-free animals. The boxes must be escapeproof and allow easy observation during an import inspection without opening the box. 6.2.4 Transport of all animals should also adhere to the NACLAR <strong>Guidelines</strong> on the Care and Use of Animals for Scientific Purposes. 6.3 TRANSPORT OF TRANSGENIC INSECTS AND THEIR PATHOGENS <strong>Genetically</strong> manipulated insects (including live insects and insect cell cultures infected with genetically manipulated pathogens) 6.3.1 The insects should be in a clearly labelled, unbreakable holding container, which is adequately sealed to prevent the insects escaping. 6.3.2 The holding container should be placed in a secondary container which is also, clearly labelled and well sealed. 6.3.3 Upon arrival, the insects should immediately be transferred from the holding container to a new container. 6.3.4 After transfer of the transported insects into new containers, all of the transport material should be decontaminated by autoclaving 6.3.5 Accounting procedures should be instigated to make sure that the same number of organisms and containers that are sent are delivered. 6.4 TRANSPORT OF TRANSGENIC PLANTS 6.4.1 Vegetative transgenic plant material should be transported within and between institutions in a primary container (for example, a plastic bag for cuttings, an envelope for seeds), which is packed in another unbreakable container. 6.4.2 The outer container should be labelled to indicate that it contains transgenic plant material, and the label should include the telephone number of a person to contact should the package be lost or damaged. Labels on seed packets should include the number of seeds being transported. 6.4.3 Whole transgenic plants should be netted and deflowered and all seed or fruit removed before transport. Plants may be transported in pots, contained in boxes or crates. 6.4.4 Accounting procedures should be instigated to make sure that the same number of plants and containers that are sent are delivered. Page 21
6.5 SUPPLY OF GENETICALLY MANIPULATED MATERIAL TO OTHER RESEARCH WORKERS 6.5.1 Investigators supplying people in Singapore with genetically manipulated material shall make sure that recipients who are unfamiliar with the genetic manipulation field are made aware of the existence of these guidelines and of the need to observe them. 6.5.2 When genetically manipulated organisms are supplied to investigators overseas, the requirements of Article 19.4 of the Convention on Biological Diversity (http://www.biodiv.org/chm/conv/art.htm), must be met. Article 19.4 stipulates that: Each Contracting Party shall, directly or by requiring any natural or legal person under its jurisdiction providing the organisms referred to in paragraph 3 above * , provide any available information about the use and safety regulations required by that Contracting Party in handling such organisms, as well as any available information on the potential adverse impact of the specific organisms concerned to the Contracting Party into which those organisms are to be introduced. To make sure that Singapore's responsibility as an exporter with respect to Article 19.4 is satisfied, individuals or organisations exporting genetically manipulated organisms must provide the following information to authorities in the recipient country. • details of the risk assessments that have been carried out in Singapore, and the conditions under which the organism has been approved for use in Singapore (e.g. contained use in a BSL2 laboratory, or small scale field trial under specified conditions); • any information known to the sender about possible adverse effects of the organism in the recipient country. (In many cases, a disclaimer that no assessment has been made of potential effects in the recipient country may be suitable.) * ‘Any living modified organism resulting from biotechnology that may have adverse effect on the conservation and sustainable use of biological diversity.’ Page 22
Page 1 and 2: THE SINGAPORE BIOSAFETY GUIDELINES
Page 3 and 4: APPENDICES Appendix 1 Other Relevan
Page 5 and 6: 1.4 DEFINITIONS OF ABBREVIATIONS Fo
Page 7 and 8: 2.2 EXEMPTIONS 2.2.1 The following
Page 9 and 10: SECTION 3: SUMMARY OF PROCEDURES 3.
Page 11 and 12: 3.3 CATEGORY A - EXPERIMENTS REQUIR
Page 13 and 14: SECTION 4: EXPERIMENTS COVERED BY T
Page 15 and 16: 4.2 CATEGORY B - EXPERIMENTS REQUIR
Page 17 and 18: SECTION 5: ROLES AND RESPONSIBILITI
Page 19 and 20: 5.2.5 Monitoring of Work The IBC sh
Page 21 and 22: • submit a new proposal form to t
Page 23: • All materials that are genetica
Page 27 and 28: 6.6.5 The form should contain any r
Page 29 and 30: BLANK PAGE
Page 31 and 32: 3. Worldwide guidelines specific to
Page 33 and 34: xiv. AS 2252.2: 1994: xv. AS 2647:
Page 35 and 36: APPENDIX 2: LIST OF GMAC-APPROVED H
Page 37 and 38: APPENDIX 3: INSTRUCTIONS FOR COMPLE
Page 39 and 40: PROPOSAL FORM FOR ASSESSMENT OF GEN
Page 41 and 42: -----------------------------------
Page 43 and 44: ) Describe the techniques to be emp
Page 45 and 46: ii) Category B iii) Category C C. R
Page 47 and 48: APPENDIX 4: TOXINS For work involvi
Page 49 and 50: 4. Procedures for handling viruses
Page 51 and 52: staff shall handle these infected a
Page 53 and 54: APPENDIX 7: REQUIREMENTS FOR GENETI
Page 55 and 56: equire the provision of a front cov
Page 57 and 58: Signs 10. An automatically-starting
Page 59 and 60: 9. All plants in the plant house sh
Page 61 and 62: APPENDIX 12: PROCEDURES FOR EXPERIM
Page 63 and 64: APPENDIX 13: DESIGN OF ANIMAL FACIL
Page 65 and 66: Other Work Being Performed in the S
Page 67 and 68: permitted in animal rooms. Personne
Page 69 and 70: APPENDIX 15: REQUIREMENTS FOR GENET
Page 71 and 72: APPENDIX 16: REQUIREMENTS FOR INSEC
Page 73 and 74: APPENDIX 17: REQUIREMENTS FOR INSEC
Page 75 and 76:
APPENDIX 18: PROCEDURES FOR EXPERIM
Page 77 and 78:
From Bio-Security Assurance Arrange
Page 79 and 80:
VIRUSES (con’t) Family and genus
Page 81 and 82:
PESTS (cont’d) INSECTS MAIN HOST
Page 83 and 84:
PESTS (cont’d) NEMATODES MAIN HOS
Page 85 and 86:
PESTS (cont’d) NEMATODES MAIN HOS
Page 87 and 88:
From the Notifiable Diseases List o
Page 89 and 90:
From the Notifiable Diseases List o
Page 91 and 92:
APPENDIX 20: GLOSSARY Note: Words a
Page 93 and 94:
fusion gamete gene gene therapy gen
Page 95 and 96:
polymerase chain reaction prion pro
show all

Biosafety Guidelines For Research On Genetically Modified ...

Create successful ePaper yourself

Delete template?

Save as template?