Biosafety Guidelines For Research On Genetically Modified ...

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The description of vectors should comprise more than a series of letters, symbols and numbers. Some description of their properties is also required. In the case of retroviral vectors, be specific and indicate what is known about their properties, and provide details of the construct, if appropriate, on a separate sheet of paper, including a genetic map and/or a description of its construction. Assessment of Potential Hazards The increasing range of hosts and vectors being used makes it imperative for every applicant to assess assiduously any potential hazards associated with the proposed work and to discuss such hazards and their containment in the proposal. Failure to do so may delay assessment until after additional information has been sought and obtained from the applicant. Details of Personnel For the ‘full details’ requested, please include the extent and nature of relevant experience on a separate sheet of paper. These details need not be sent to GMAC but should be checked by the IBC. Proposal Form A copy of the proposal form is attached to this Appendix. The proposal form is selfduplicating and allows for sufficient copies to be made for GMAC, the IBC and the principal investigator’s records. Please note that GMAC requires the originals (i.e. top copies) of forms to be submitted, and not photocopies. Appendix - Page 9
PROPOSAL FORM FOR ASSESSMENT OF GENETIC MANIPULATION WORK GMAC Ref No.: ___________ (for official use only) Name of Scientist(s) : Name of Institution : Type of Experimental Organisms (please tick) : Animal Plant Others, please specify: Experiment Risk Group (please tick) : Category A Category B Category C A. Experimental detail (attach separate sheet if necessary) 1. Project title 2. Research unit involved 3. Experimental objective 4. Rationale for the experiment 5. Duration of the experiment Proposal Form for Assessment of Genetic Manipulation (Page 1 of 3)
Page 1 and 2: THE SINGAPORE BIOSAFETY GUIDELINES
Page 3 and 4: APPENDICES Appendix 1 Other Relevan
Page 5 and 6: 1.4 DEFINITIONS OF ABBREVIATIONS Fo
Page 7 and 8: 2.2 EXEMPTIONS 2.2.1 The following
Page 9 and 10: SECTION 3: SUMMARY OF PROCEDURES 3.
Page 11 and 12: 3.3 CATEGORY A - EXPERIMENTS REQUIR
Page 13 and 14: SECTION 4: EXPERIMENTS COVERED BY T
Page 15 and 16: 4.2 CATEGORY B - EXPERIMENTS REQUIR
Page 17 and 18: SECTION 5: ROLES AND RESPONSIBILITI
Page 19 and 20: 5.2.5 Monitoring of Work The IBC sh
Page 21 and 22: • submit a new proposal form to t
Page 23 and 24: • All materials that are genetica
Page 25 and 26: 6.5 SUPPLY OF GENETICALLY MANIPULAT
Page 27 and 28: 6.6.5 The form should contain any r
Page 29 and 30: BLANK PAGE
Page 31 and 32: 3. Worldwide guidelines specific to
Page 33 and 34: xiv. AS 2252.2: 1994: xv. AS 2647:
Page 35 and 36: APPENDIX 2: LIST OF GMAC-APPROVED H
Page 37: APPENDIX 3: INSTRUCTIONS FOR COMPLE
Page 41 and 42: -----------------------------------
Page 43 and 44: ) Describe the techniques to be emp
Page 45 and 46: ii) Category B iii) Category C C. R
Page 47 and 48: APPENDIX 4: TOXINS For work involvi
Page 49 and 50: 4. Procedures for handling viruses
Page 51 and 52: staff shall handle these infected a
Page 53 and 54: APPENDIX 7: REQUIREMENTS FOR GENETI
Page 55 and 56: equire the provision of a front cov
Page 57 and 58: Signs 10. An automatically-starting
Page 59 and 60: 9. All plants in the plant house sh
Page 61 and 62: APPENDIX 12: PROCEDURES FOR EXPERIM
Page 63 and 64: APPENDIX 13: DESIGN OF ANIMAL FACIL
Page 65 and 66: Other Work Being Performed in the S
Page 67 and 68: permitted in animal rooms. Personne
Page 69 and 70: APPENDIX 15: REQUIREMENTS FOR GENET
Page 71 and 72: APPENDIX 16: REQUIREMENTS FOR INSEC
Page 73 and 74: APPENDIX 17: REQUIREMENTS FOR INSEC
Page 75 and 76: APPENDIX 18: PROCEDURES FOR EXPERIM
Page 77 and 78: From Bio-Security Assurance Arrange
Page 79 and 80: VIRUSES (con’t) Family and genus
Page 81 and 82: PESTS (cont’d) INSECTS MAIN HOST
Page 83 and 84: PESTS (cont’d) NEMATODES MAIN HOS
Page 85 and 86: PESTS (cont’d) NEMATODES MAIN HOS
Page 87 and 88: From the Notifiable Diseases List o
Page 89 and 90:
From the Notifiable Diseases List o
Page 91 and 92:
APPENDIX 20: GLOSSARY Note: Words a
Page 93 and 94:
fusion gamete gene gene therapy gen
Page 95 and 96:
polymerase chain reaction prion pro
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