Biosafety Guidelines For Research On Genetically Modified ...

More documents

Recommendations

Info

5. Ensure that the experimental protocol complies with standard requirements for experiments involving animals. 6. Notify GMAC of the IBC certification of the transgenic-animal holding facilities, and send a copy of the assessment and proposal forms, including IBC advice to relevant regulatory authorities for notification (if necessary). Appendix - Page 25
APPENDIX 13: DESIGN OF ANIMAL FACILITIES Introduction Facilities for laboratory animals used for studies for genetic manipulation work of either an infectious or non-infectious nature should be physically separated from other activities such as animal production and animal quarantine. Animals under experiment may be either small laboratory animals (e.g., mice, rabbits) or large domestic animals (e.g., pigs, sheep, cattle). The requirements for the housing and maintenance of the animals may differ in scale as a result, but the microbiological safety principles are similar. Housing of transgenic animals The particular point of concern with transgenic animals is that the result of any insertion of novel genetic material into the genome of an animal is unpredictable, both in terms of the expression of the new genetic material and regarding the effect of this material on neighbouring genes. Furthermore, any escape of the novel genetic material through either the escape of transgenic animals or through their interbreeding with wild or uncontained animals is potentially irreversible. The containment for transgenic animals varies in different experiment systems. The nature of the containment required depend on the type of animal, the stages in the animals’ life cycle that will be involved in the work, the number to be used, and the nature of the genetic manipulation. Housing of infectious animals Points to consider for the housing of animals in which infectious agents have been used, including transgenic animals produced by infectious agents. 1. The animal housing must comply with the NACLAR guidelines on the care and use of animals for scientific purposes. 2. Laboratory animal facilities are an extension of the laboratory and may be integral to, and inseparable from, the laboratory. 3. As a general principle, the biological and physical containment recommended for working with infectious agents in vivo and in vitro are comparable. 4. The physical containment levels for work with infectious genetically manipulated animals follow the animal containment levels GA-BSL2 or GA-BSL3 as appropriate for the pathogen. Requirements for GA-BSL2 and GA-BSL3 animal containment facilities are set out in Appendices 14 and 15. Appendix - Page 26
Page 1 and 2:
THE SINGAPORE BIOSAFETY GUIDELINES
Page 3 and 4:
APPENDICES Appendix 1 Other Relevan
Page 5 and 6:
1.4 DEFINITIONS OF ABBREVIATIONS Fo
Page 7 and 8:
2.2 EXEMPTIONS 2.2.1 The following
Page 9 and 10:
SECTION 3: SUMMARY OF PROCEDURES 3.
Page 11 and 12: 3.3 CATEGORY A - EXPERIMENTS REQUIR
Page 13 and 14: SECTION 4: EXPERIMENTS COVERED BY T
Page 15 and 16: 4.2 CATEGORY B - EXPERIMENTS REQUIR
Page 17 and 18: SECTION 5: ROLES AND RESPONSIBILITI
Page 19 and 20: 5.2.5 Monitoring of Work The IBC sh
Page 21 and 22: • submit a new proposal form to t
Page 23 and 24: • All materials that are genetica
Page 25 and 26: 6.5 SUPPLY OF GENETICALLY MANIPULAT
Page 27 and 28: 6.6.5 The form should contain any r
Page 29 and 30: BLANK PAGE
Page 31 and 32: 3. Worldwide guidelines specific to
Page 33 and 34: xiv. AS 2252.2: 1994: xv. AS 2647:
Page 35 and 36: APPENDIX 2: LIST OF GMAC-APPROVED H
Page 37 and 38: APPENDIX 3: INSTRUCTIONS FOR COMPLE
Page 39 and 40: PROPOSAL FORM FOR ASSESSMENT OF GEN
Page 41 and 42: -----------------------------------
Page 43 and 44: ) Describe the techniques to be emp
Page 45 and 46: ii) Category B iii) Category C C. R
Page 47 and 48: APPENDIX 4: TOXINS For work involvi
Page 49 and 50: 4. Procedures for handling viruses
Page 51 and 52: staff shall handle these infected a
Page 53 and 54: APPENDIX 7: REQUIREMENTS FOR GENETI
Page 55 and 56: equire the provision of a front cov
Page 57 and 58: Signs 10. An automatically-starting
Page 59 and 60: 9. All plants in the plant house sh
Page 61: APPENDIX 12: PROCEDURES FOR EXPERIM
Page 65 and 66: Other Work Being Performed in the S
Page 67 and 68: permitted in animal rooms. Personne
Page 69 and 70: APPENDIX 15: REQUIREMENTS FOR GENET
Page 71 and 72: APPENDIX 16: REQUIREMENTS FOR INSEC
Page 73 and 74: APPENDIX 17: REQUIREMENTS FOR INSEC
Page 75 and 76: APPENDIX 18: PROCEDURES FOR EXPERIM
Page 77 and 78: From Bio-Security Assurance Arrange
Page 79 and 80: VIRUSES (con’t) Family and genus
Page 81 and 82: PESTS (cont’d) INSECTS MAIN HOST
Page 83 and 84: PESTS (cont’d) NEMATODES MAIN HOS
Page 85 and 86: PESTS (cont’d) NEMATODES MAIN HOS
Page 87 and 88: From the Notifiable Diseases List o
Page 89 and 90: From the Notifiable Diseases List o
Page 91 and 92: APPENDIX 20: GLOSSARY Note: Words a
Page 93 and 94: fusion gamete gene gene therapy gen
Page 95 and 96: polymerase chain reaction prion pro
show all

Biosafety Guidelines For Research On Genetically Modified ...

Create successful ePaper yourself

Delete template?

Save as template?