Supplementum 3+4/2007 - SpoleÄnost pro pojivové tkánÄ›
Supplementum 3+4/2007 - SpoleÄnost pro pojivové tkánÄ›
Supplementum 3+4/2007 - SpoleÄnost pro pojivové tkánÄ›
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ABSTRACT<br />
LABORATORY MONITORING<br />
OF BIOCHEMICAL CHANGES IN<br />
EROSIVE OSTEOARTHRITIS OF<br />
THE HANDS BY DETERMINATION<br />
OF SELECTED BIOMARKERS OF<br />
CONNECTIVE TISSUE METABOLISM<br />
Braun M., Hulejová H., Olejárová M., Pavelková A.,<br />
Gatterová J., Šenolt L., Pavelka K.<br />
Institute of Rheumatology, Prague, Czech Republic<br />
E-mail: braun@revma.cz<br />
Introduction<br />
Although most of studies concerning<br />
osteoarthritis (OA) is focused in hip or<br />
knee joints, erosive osteoarthritis (EOA) is<br />
most frequently localized in <strong>pro</strong>ximal and<br />
distal interphalangeal joints of the hands.<br />
When compared with non-erosive form, in<br />
presence of erosions there are much more<br />
serious complications such as joint destruction<br />
and local inflammation <strong>pro</strong>cesses in<br />
joint compartments.<br />
Our aim in this study was to monitor<br />
and compare the selected biomarkers of<br />
connective tissues in patients with hand<br />
OA in effort to quantify and review the differences<br />
between erosive and non-erosive<br />
OA by means of laboratory assessment of<br />
important indicators of connective tissue<br />
remodelling and inflammation.<br />
Patients and methods<br />
In total 47 patients with hand EOA<br />
(average age 64 years) and 24 with non-<br />
-erosive OA (average age 62 years) were<br />
followed-up.<br />
316 The 9 th Prague-Sydney-Lublin Symposium
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