Supplementum 3+4/2007 - Společnost pro pojivové tkáně

From the laboratory parameters we analysed
levels of pentosidine (PEN) in serum
and urine by HPLC, urinary deoxypyridinoline
(DPD) by immunochemiluminiscence
method using IMMULITE analyser, serum
level of hyaluronic acid (HA) was measured
by ELISA, C-reactive protein (CRP)
and total protein amount in serum as well
as urinary creatinine were determined by
means of biochemical analyzer Olympus
AU400. Within the longitudial study monitoring
of OA progression and therapeutic
effects is intended as well as repeated withdrawals
of body fluids in 1 year intervals
for laboratory analysis.
Results
In case of EOA was observed increased
remodelling activity of connective
tissues compared to OA without erosions.
Catabolic processes in bone and cartilage
in erosive form were reflected by mild
elevation of PEN levels such as representative
of advanced glycation end-product and
significant increase of DPD compared with
non-erosive OA. In addition, in EOA was
statistically increased the concentration of
HA (two-fold) indicating local inflammation
in affected joints, nevertheless there
was no difference in serum CRP between
both the OA groups.
Conclusions: Based on the above-mentioned
results it is possible to assume
that there is a relationship between local
synovial inflammation, infliction of the
individual joint compartments and their
morphological changes. The selected biomarkers
can thus reflect the connective
tissue changes and can represent suitable
supplement to clinical and x-ray findings
when studying differences between erosive
and non-erosive OA.
Supported by the Ministry of Health
of the Czech Republic – grant IGA No.
NR/8447-4 and research project No.
00023728.
REVIEW ARTICLE
KŘIVICE – STÁLE AKTUÁLNÍ
PROBLÉM
RICKETS STILL ACTUAL PROBLEM
Mařík I., Myslivec R., Maříková A., Hyánková E.
Ambulantní centrum pro vady pohybového
aparátu
Olšanská 7, 130 00, Praha 3
E-mail: ambul_centrum@volny.cz
Summary
The paper summarizes recent substantial
knowledge on both rickets and
osteomalacia – pathogenetic congeneric
disturbance of calcium homeostasis maintenance
caused by deficiency of vitamin
D and calcium in food at insufficiency of
sun shine. Convenient radio-clinical development
and bone remodelling during
supplementation by vitamin D3 (cholecalciferol),
calcium and other calciotropic
drugs at the metabolic osteopathies should
be monitored by biochemical markers of
bone metabolism (ionized calcium, inorganic
phosphorus, total alkaline phosphatase
and its isoenzyme, osteocalcin, urine pyridinoline
and deoxypyridinoline). The case
reports demonstrate radio-clinical findings
and treatment results of acute vitamin D
deficiency rickets (VDR), hypophosphatemic
rickets and hypophosphatasia with
Looser´s zones. The authors point out
ambul_centrum@volny.cz
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