Book of Abstracts - Ruhr-Universität Bochum

P-47
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Organometallic Ruthenium and Osmium Complexes with Carbohydrate-Based
Ligands as Anticancer Agents
Alexey A. Nazarov, a * Muhammad Hanif, b Lucienne Juillerat-Jeanneret, a Christian G.
Hartinger, b Olivier Zava, a Michael A. Jakupec, b Bernhard K. Keppler, b Paul J. Dyson a
a Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL),
CH-1015 Lausanne, Switzerland.
b University of Vienna, Institute of Inorganic Chemistry, Waehringer Str. 42, A-1090, Vienna,
Austria.E-mail: alexey.nazarov@epfl.ch
Half-sandwich organometallic compounds have attracted increasing interest due to their potential as
anticancer drugs. 1 Different approaches have been explored, including mono- and bifunctional
compounds such as RAPTA compounds, targeted approaches, kinase inhibitors, ruthenium-arene
clusters and polynuclear ruthenium arene compounds. Increase of glucose uptake in malignant cells
due to upregulation of glycolysis and glucose transporters in comparison to healthy cells is almost
universal for cancer cells. Attaching a carbohydrate moiety to a Ru or Os center provides new metalbased
compounds that exploit the biochemical and metabolic functions used for sugars in living
organisms for transport and accumulation. 2,3
This presentation will focus on synthesis of new sugar containing ruthenium(II) and osmium(II)–arene
complexes and their characterization in terms of stability and cytotoxicity. The structural modification
with regard to the arene ligand, the leaving group, and the nature the metal centers is discussed.
The authors are indebted to the EU for a Marie Curie Intra European Fellowship within the
7th European Community Framework Programme project 220890-SuRuCo (A.A.N.) and the
Higher Education Commission of Pakistan (M.H.).
References
1. C. G. Hartinger and P. J. Dyson, Chem. Soc. Rev., 2009, 38, 391-401.
2. C. G. Hartinger, A. A. Nazarov, S. M. Ashraf,; P. J. Dyson, B. K. Keppler, Curr. Med. Chem.,
2008, 15, 2574-2591.
3. I. Berger, M. Hanif, A. A. Nazarov, C. G. Hartinger, R. O. John, M. L. Kuznetsov, M. Groessl, F.
Schmitt, O. Zava, F. Biba, V. B. Arion, M. Galanski, M. A. Jakupec, L. Juillerat-Jeanneret, P. J.
Dyson, B. K. Keppler, Chem. Eur. J. 2008, 14, 9046 – 9057.
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