Book of Abstracts - Ruhr-Universität Bochum
Book of Abstracts - Ruhr-Universität Bochum
Book of Abstracts - Ruhr-Universität Bochum
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
P-53<br />
ISBOMC `10 5.7 – 9.7. 2010 <strong>Ruhr</strong>-<strong>Universität</strong> <strong>Bochum</strong><br />
Silicium dioxide nanoparticles as carriers<br />
for bio-active organometal complexes<br />
Gregor Dördelmann a and Ulrich Schatzschneider a *<br />
a Lehrstuhl für Anorganische Chemie I – Bioanorganische Chemie, <strong>Ruhr</strong>-<strong>Universität</strong> <strong>Bochum</strong>,<br />
<strong>Universität</strong>sstr. 150, D-44801 <strong>Bochum</strong>, Germany, E-Mail: gregor.doerdelmann@rub.de.<br />
.<br />
CO-releasing molecules (CORMs) find steadily increasing use as a stable storage form <strong>of</strong> carbon<br />
monoxide for potential therapeutic applications. Several compounds reported, such as<br />
[Mn(CO)3(tpm-L1)]PF6, show significant cytotoxicity after photoactivation, comparable to that <strong>of</strong> the<br />
established anticancer agent 5-fluorouracil (5-FU). [1,2]<br />
Most solid tumors possess unique pathophysiological characteristics that are not observed in normal<br />
tissue, like leaky vasculature and impaired lymphatic drainage, leading to an enhanced permeability<br />
and retention (EPR) <strong>of</strong> macromolecules in the malignant tissue. [3] Thus, we wanted to explore whether<br />
silicium dioxide nanoparticles can be utilized as delivery agents for CORMs in solid tumors.<br />
SiO 2<br />
N 3<br />
CuSO 4 5H 2O<br />
Na-ascorbate<br />
SiO 2<br />
+<br />
O<br />
tButOH, H 2O<br />
N<br />
N<br />
N<br />
O<br />
N N<br />
N N<br />
N N<br />
N N<br />
N N<br />
N N<br />
Mn CO<br />
CO<br />
CO<br />
Mn CO<br />
CO<br />
CO<br />
Silicium dioxide nanoparticles containing the azidopropyl group were prepared by emulsion<br />
copolymerization <strong>of</strong> tetraethylorthosilicate and (3-azidopropyl)triethoxysilane. [4] This procedure<br />
provides a reproducible synthesis <strong>of</strong> particles in the ~90 nm size regime as determined by transmission<br />
electron microscopy (TEM) and dynamic light scattering (DLS). The presence <strong>of</strong> the azido groups and<br />
the manganese CORM on the surface <strong>of</strong> the particles was analysed by spectroscopic methods like<br />
UV/VIS, IR and NMR spectroscopy as well as energy dispersive X-ray spectroscopy (EDX).<br />
Reference<br />
1. J. Niesel, A. Pinto, H.W. Peindy N’Dongo, K. Merz, I. Ott, R. Gust, U. Schatzschneider, Chem.<br />
Commun. 2008, 1798-1800.<br />
2. H. Pfeiffer, A. Rojas, J. Niesel and U. Schatzschneider, Dalton Tran . 2009, 4292-4298.<br />
3. I. Brigger, C. Dubernet, P. Couvreur, Adv. Drug Delivery Rev. 2002, 54, 631-651.<br />
4. C. A. Bradley, B. D. Yuhas, M. J. McMurdo, T. D. Tilley, Chem. Matter. 2009, 21, 174-185.<br />
111
Change language