Book of Abstracts - Ruhr-Universität Bochum

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ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Coordination Behavior and Spectroscopic Studies of Biologically Active
Organotin(IV) Complexes of 2-(N-naphthylamido)benzoic Acid
Khadija Shahid a�
a Riphah Institute of Pharmaceutical, Sciences 7 th Avenue, G-7/4, Riphah International
University, Islamabad-45320 Pakistan
New organotin(IV)complexes of 2-(N-naphthylamido)benzoic acid were synthesized in
stoichiometric ratio in anhydrous toluene under the reflux yield the organotin(IV) carboxylates with
general formula R 4-nSnLn(R= Me, n-Bu, Ph, n-Oct, Bz and n= 2, 3). All the complexes have been
characterized by various spectroscopic methods (IR, 1 H, 13 C, 119 Sn NMR) and mass spectrometry. 1
Cytotoxicity of the synthesized compounds was checked against Brine-shrimp larvae.
In vitro activities against some Gram-positive and Gram-negative bacteria and fungi were also
determined. 2 Antimicrobial activities show that species with tetrahedral geometry in solution are
more toxic. 3
References
Scheme: Synthesis of Di/Tri organotin Complexes.
1. (a) K. Shahid, S. Ali, S. Shahzadi, J. Coord. Chem. 2009, 62(17), 2919–2926. (b) K. Shahid, S.
Shahzadi, J. Serb Chem. Soc. 2009, 74(2), 141-154.
2. A. Rahman, M.I. Choudhary, W.J. Thomsen, Bioassay Techniques for Drug Development;
Hardward Academic Press, Amsterdam 2001.
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