Book of Abstracts - Ruhr-Universität Bochum

P-28
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Synthesis, Structure and Anticancer Activity of new Complexes of Copper
with Pyridoxal-semicarbazone
Violeta Jevtovic, *a Dragoslav Vidovic, b Radmila Kovacecic, c and Sonja Kaisarevic c
a University of Novi Sad, Faculty of Sciences, Department of Chemistry, D. Obradovica 3, 38121,
Novi Sad, Serbia
b University of Oxford, Chemical Research Laboratory,Masfield Road ,OX1 3TA, City, UK.
c University of Novi Sad, Faculty of Sciences, Department of Biology, D. Obradovica 3, 38121, Novi
Sad, Serbia. E mail: violeta.jevtovic@dh.uns.ac.rs
With reaction of ligand pyridoxal-semicarbazone PLSC . 2H2O 1 and appropriate chloride, sulphate
and thiocyanate salts Cu(II) in alcohol and water mixtures which were given in three new copper(II)
complexes: [Cu(PLSC)Cl2](1),[Cu(PLSC)(H2O)(SO4)]2 . 3H2O(2), [Cu(PLSC)2(NCS)2](NCS)2 (3)
(see Fig.1). Cytototoxic activity was evaluated by colorimetric sulforhodamine B (SRB) assay, after
exposure of cells to tested compounds for 24 h and 72 h. (see Fig 2.) shows effect of different
concentrations of tested compounds on two cell lines after 24 h and 72 h incubation times. The results
suggest that compound (A) exibit no antiproliferative effect. Compound (B) exibit cytotoxic effects
on both cell lines only after 72h treatment by the highest tested concentrations. Similar cytotoxicity
patern was observed for compound (C) with aditional cytotoxic effect on MDA-MB-231 after 24 h
treatment with the highest concentration.
(1) (2) (3)
Figure 1. The molecular structure of complexes
Figure 2. Effects of compounds (1), (2) and (3) on cell proliferation of MCF7 and MDA-MB-231
References
1. V. Leovac, V.S. Jevtovic, Lj. Jovanovic, G.A. Bogdanovic, J. Serb. Chem. Soc. 2005, 70, 393-422.
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