Book of Abstracts - Ruhr-Universität Bochum

OP-4
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Metallo-Nucleosides: Bis(dicobalt hexacarbonyl alkynyl) Derivatives of
2'-Deoxyuridine. Synthesis and Evaluation of Antiproliferative Activity Against
Human Breast Cancer Cells
Roman Dembinski, *a Przemyslaw Wyrebek. a Agnieszka Mikus. a Adam Sniady,. a Laura Hamel, b
and Ingo Ott *b
a Oakland University, Department of Chemistry, 2200 N. Squirrel Rd., 48309-4477, Rochester, MI,
USA. b Technische Universität Braunschweig, Institute of Pharmaceutical Chemistry, Beethovenstr.
55, 38106 Braunschweig, Germany, E-mail: dembinsk@oakland.edu
In continuation of synthetic pursuit of metallo-nucleosides, in particular dicobalt
hexacarbonyl 5-alkynyl-2'-deoxyuridines, 1 novel compounds with two alkynyl groups were
synthesized starting from 5-iodo-2'-deoxyuridine (selected example is illustrated below). The
complexes have been examined for their anti-cancer activity in vitro against MCF-7 and
MDA-MB-231 human breast cancer cell lines or HT-29 (colon carcinoma). The results were
compared to activity of non-coordinated alkynyl precursors.
References
HO
O
HN
O
OH
O
N
(CO) 3
Co Co(CO) 3
20
H
Co(CO) 3
Co(CO) 3
1. (a) C. D. Sergeant, I. Ott, A. Sniady, S. Meneni, R. Gust, A. L. Rheingold, R. Dembinski, Org.
Biomolec. Chem. 2008, 6, 73-80. (b) I. Ott, B. Kircher, R. Dembinski, R. Gust, Expert Opin.
Therapeutic Pat. 2008, 18, 327-336.