Book of Abstracts - Ruhr-Universität Bochum

P-59
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Synthesis, Characterization and Properties of the Cluster Rhenium(ІІІ)
Compound with β-Alanine Ligands
Mariia S. Randarevych, a Kateryna A. Zablotska, a Konstantin V. Domasevitch, b Alexander V.
Shtemenko a
a Department of Inorganic Chemistry, Ukrainian State Chemical Technological University, Gagarin
Ave. 8, Dnipropetrovs’k 49005, Ukraine. E-mail: shtemenko@ukr.net. b Department of Inorganic
Chemistry, Kiev University, Volodimirska Street 64, Kiev 01033, Ukraine. E-mail: dk@univ.kiev.ua.
The theoretical interest in binuclear complex compounds of dirhenium(ІІІ) is caused by the fact that
rhenium is one of the few elements that are able to form a multiplet metal-metal bond. From the
practical point of view, these compounds can be used in medical practice since they have
anticancerogenic, antihemolytic, and antiradical properties and lower toxicity in comparison with
other well-known compounds of transition metals.
One of the received cluster compounds of dirhenium(ІІІ) with γ-aminobutyric acid’s ligands has
already shown excellent antitumor properties. 1 Owing to this, our purpose is to expand the range of
similar compounds by using other amino acids as ligands which possess own biological activity.
Therefore, the synthesis of new cluster aminocarboxylates of dirhenium(III) and the study of their
physicochemical and biological properties are of great interest for us. A synthetic procedure of
dirhenium(ІІІ) complex compound with β-alanine was developed. The properties of this compound are
investigated by spectral method. The compound cis-Re2Cl6{�-AlaH}2 ·1.5H2O is shown to consist of
coordinating centre Re2 6 + with quadruple bond rhenium-rhenium. In equatorial positions there are
bridge groups containing β-alanine residues being in cys-position relative to Re-Re. The structure of
the given compound is presented on fig. 1.
Fig.1 cis-Re2Cl6{�-AlaH}2 ·1.5H2O
The structure of this compound is confirmed by direct X-ray structure, thermal and spectral analyses.
We have also investigated the biological activity of the complex that revealed itself perspective as a
cytostatic and anticancer agent.
References
1. A. Shtemenko, P. Collery, N. Shtemenko, K. Domasevitch, E. Zabitskaya, A. Golichenko Dalton
Trans. 2009, 26, 5132 - 5136.
117