Book of Abstracts - Ruhr-Universität Bochum

P-76
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Synthesise of New Butyl Tin(IV) Compounds and Investigation About Their
Toxicity and Anti-inflammatory Studies
Fatemeh Tavakolinia, a Mohammad Yousefi, a Saeed Amanpour, b Samad Mohammadnejad, b
and Mojdeh Safari *b
a Azad University, Shahre-rey Branch, Tehran, Iran
b Experimental Lab, Cancer Research center, Tehran university of medicinal sciences, Tahran, Iran.
E-mail: ftavakolinia@yahoo.com
Chemistry of organotin(IV) complexes has developed considerably during the last 30 years,
highlighting the synthesis of a number of complexes with interesting properties. 1-3 One of the most
important bioinorganic chemistry research areas as regards organotin compound is the investigation
of their cytotoxic/antitumor activities. In addition many organotin(IV) compounds have been tested for
their in vitro activity against a large variety of tumor lines and have been found to be as effective or
better than traditional heavy metal anticancer drugs such as Cis-platin. 4,5 In general, toxicity of
organotin(IV) compounds seems to increase with the chain length of the organic alkyl group, which
are often more active than aryl ones, and follow the order R3Sn> R2Sn> RSn. 6 In this research three
new organotin(IV) complexes of the general formula R3SnŔ and R2SnŔ2 (where R=Ph, Bu, and Ŕ=1-
Butane, 2-Butane, Ph) have been synthesized by the Grignard reaction of triphenyltin chloride with 1iodo
butane and 2-chloro butane in 1:1 molar ratio and the reaction of dibutyltin dichloride with chloro
benzene in 1:2 molar ratio. The resulted complexes are Ph3Sn1-Bu (1), Ph3Sn2-Bu (2), Ph2SnBu2 (3).
The sample of synthesise of one of the complexes comes below. These new derivatives have been
characterized by FT-TR, 1 H, 13 C, 119 Sn NMR and Mass spectroscopy. The toxicity study and antiinflammatory
effect are going to carry out and the LD50 value is going to determine.
ICH2CH2CH2CH3 + Mg � IMgCH2CH2CH2CH3
IMgCH2CH2CH2CH3 + Ph3SnCl � Ph3SnCH2CH2CH2CH3 (1) + MgClI
References
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3. L.Pellerito, L.Nagy, Chem. Rev. 2002, 224, 111.
4. M. Gielen, App. Organomet. Chem.2002, 16, 481.
5. M. Gielen, Coord. Chem. Rev. 1996, 26, 1.
6. D. Dc Vos, R.Willem, M. Gielen, K. E. Van Wingerden, K. K. Nooter, Net. Based drugs 1998, 5.
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