Book of Abstracts - Ruhr-Universität Bochum

P-79
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Tris(pyrazolyl)borates as Versatile Ligands in the Synthesis of Bioorganometallic
Compounds
Johannes Zagermann, a Matthew C. Kuchta, a Klaus Merz, a Nils Metzler-Nolte a*
a Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Universitätsstraße 150,
44801 Bochum, Germany, Johannes.Zagermann@rub.de
While cyclopentadienyl (Cp) containing compounds such as ferrocene have found various applications
in bioorganometallic chemistry, little work is found concerning analogue compounds containing Cp
surrogates. As such, we have been interested in exploiting the rich coordination chemistry of
tris(pyrazolyl)borate (Tp) ligands for the synthesis of bioconjugates with possible applications in
biomedical, electrochemical or spectroscopical studies.
We describe the synthesis and characterization of mixed ligand (Cp/Tp) and (Tp/Tp') ruthenium
sandwich compounds, 1 both incorporating a “third-generation” p-BrC6H4Tp (Tp') ligand, 2 and their
application in the formation of peptide bioconjugates. More recently, we utilized iodocarbonyltungsten
complexes containing a regular Tp* ligand to label peptides via η 2 -coordinated alkyne ligands
including the unusual amino acid propargylglycine. 3
References
1. (a) J. Zagermann, M. C. Kuchta, K. Merz, N. Metzler-Nolte, J. Organomet. Chem. 2009, 694, 862-
867.
(b) J. Zagermann, M. C. Kuchta, K. Merz, N. Metzler-Nolte, manuscript in preparation.
2. J. Zagermann, M. C. Kuchta, K. Merz, N. Metzler-Nolte, Eur. J. Inorg. Chem. 2009, 5407-5412.
3. J. Zagermann, K. Merz, N. Metzler-Nolte, Organometallics 2009, 28, 5090-5095.
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