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Book of Abstracts - Ruhr-Universität Bochum

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P-79<br />

ISBOMC `10 5.7 – 9.7. 2010 <strong>Ruhr</strong>-<strong>Universität</strong> <strong>Bochum</strong><br />

Tris(pyrazolyl)borates as Versatile Ligands in the Synthesis <strong>of</strong> Bioorganometallic<br />

Compounds<br />

Johannes Zagermann, a Matthew C. Kuchta, a Klaus Merz, a Nils Metzler-Nolte a*<br />

a Fakultät für Chemie und Biochemie, <strong>Ruhr</strong>-<strong>Universität</strong> <strong>Bochum</strong>, <strong>Universität</strong>sstraße 150,<br />

44801 <strong>Bochum</strong>, Germany, Johannes.Zagermann@rub.de<br />

While cyclopentadienyl (Cp) containing compounds such as ferrocene have found various applications<br />

in bioorganometallic chemistry, little work is found concerning analogue compounds containing Cp<br />

surrogates. As such, we have been interested in exploiting the rich coordination chemistry <strong>of</strong><br />

tris(pyrazolyl)borate (Tp) ligands for the synthesis <strong>of</strong> bioconjugates with possible applications in<br />

biomedical, electrochemical or spectroscopical studies.<br />

We describe the synthesis and characterization <strong>of</strong> mixed ligand (Cp/Tp) and (Tp/Tp') ruthenium<br />

sandwich compounds, 1 both incorporating a “third-generation” p-BrC6H4Tp (Tp') ligand, 2 and their<br />

application in the formation <strong>of</strong> peptide bioconjugates. More recently, we utilized iodocarbonyltungsten<br />

complexes containing a regular Tp* ligand to label peptides via η 2 -coordinated alkyne ligands<br />

including the unusual amino acid propargylglycine. 3<br />

References<br />

1. (a) J. Zagermann, M. C. Kuchta, K. Merz, N. Metzler-Nolte, J. Organomet. Chem. 2009, 694, 862-<br />

867.<br />

(b) J. Zagermann, M. C. Kuchta, K. Merz, N. Metzler-Nolte, manuscript in preparation.<br />

2. J. Zagermann, M. C. Kuchta, K. Merz, N. Metzler-Nolte, Eur. J. Inorg. Chem. 2009, 5407-5412.<br />

3. J. Zagermann, K. Merz, N. Metzler-Nolte, Organometallics 2009, 28, 5090-5095.<br />

137

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