Book of Abstracts - Ruhr-Universität Bochum

P-84
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
New Oxorhenium(V) Complex with Aminothiazole Ligand, and Radiochemical
Behavior of its Oxotechnetium(V) Complex Analog
Norah S. Al-Hokbany, a* R.M. Mahfouz, a and I.J. Al-Jammaz b
a King Saud University, Department of Chemistry, College of Science, P.O.Box 2455, Riyadh, 11451
Kingdom of Saudi Arabia. b Cyclotron and Radiopharmaceuticals Department, King Faisal Specialist
Hospital and Research Center. P.O. Box 3354, Riyadh 11211, Kingdom of Saudi Arabia.
Tel:+966 1 4772245; Fax: +966 1 4772245. e-mail: nhokbany@ksu.edu.sa
A [ReO(amino)2OH] complex was successfully synthesized by ligand exchange method of
oxorhenuim gluconate with aminothiazole ligand. Geometry optimization of complex has been carried
out using DFT at the B3LYP/LANL2DZ functional in singlet state. B3LYP predicted infrared
spectrum of geometrical optimized structure using the same level of the theory and the same basis set
showed good agreement with experimentally observed values. The complex has been characterized
using elemental analysis and different spectroscopic techniques (IR, UV-Vis, NMR and MS).
At the technetium tracer level, the 99m TcO-complex has been synthesized by two methods ( 99m Tcgluconate
as precursor; direct reduction). The radiochemical purity of the complex was over 95% as
measured by thin layer chromatography. In vitro studies showed that the complex possessed good
stability under physiological conditions. Its partition coefficient indicated that it was a hydrophilic
complex. The electrophoresis results showed the complex was neutral. Normal biodistribution of 99m
Tc complex, exhibit high lung, liver and spleen uptake (27%, 11%, and 12%, respectively). Blood and
lung clearance was quite fast (% injection dose in blood and lungs 0.36% and 0.18%, respectively at 1
hr post-injection), while liver activity remained high for a longer period (% injection dose 12% at 1 hr
post-injection). The radioactivity from the novel technetium complex was excreted mainly through the
hepatobiliary system (35% at 1 h post-injection) and partially kidney.
References
pH=9
r.t
45min
99m TcO4 -
NaBH 4
Na-gluconate
SnCl2. 2H2O 99m TcO(gluc)2 -
+
NH
O
M
N S
OH
N
S NH2 S
HN
were M = Re, 99m Tc
142
N
ReO 4 -
Na-gluconate
SnCl 2. 2H 2O
ReO(gluconate) 2 -
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