Book of Abstracts - Ruhr-Universität Bochum

P-37
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Cytotoxicity Studies on Rhenium(I) Tricarbonyl Complexes
Teck-Tian Wong, Li-Peng Wong, Peng-Foo Peter Lee and Yaw-Kai Yan*
Nanyang Technological University, National Institute of Education, Natural Sciences & Science
Education Department, 1 Nanyang Walk, Singapore 637616. E-mail: yawkai.yan@nie.edu.sg
Since the late 1980’s, there has been a steady growth of interest in ruthenium anti-cancer drugs as
reflected in the accelerating growth of publications in this area. 1 In particular, a series of water soluble
and stable ruthenium(II) arene ethylenediamine complexes (1) was shown to exhibit promising anticancer
activity in vitro and in vivo. 2 Anti-cancer activity has also been observed in rhenium(I)
tricarbonyl complexes. 3 Since both rhenium(I) and ruthenium(II) are d 6 configuration metal ions, it
would be interesting to investigate the anti-cancer activity of rhenium(I) tricarbonyl complexes with
N,N- and P,P- chelating agents. The three CO ligands of the Re(I) complexes correspond to the arene
ligand of the Ru(II) complexes in that both donate six electrons. The chelating N,N- and P,P- ligands
of the Re(I) complexes correspond to the ethylenediamine ligand of the Ru(II) complexes and both
types of complexes have a single ligand exchange site occupied by a monoanionic ligand.
In this study, we are concerned with the synthesis and bio-physicochemical characterization of a series
of mononuclear rhenium(I) tricarbonyl complexes [Re(X)(CO)3L2] (2) [where X = Br, Cl, Cl2HCCO2;
L2 = ethylenediammine (en), N,N,N ′ ,N ′ -tetramethylethylenediamine (tmen), 2,2 ′ -bipyridine (bpy),
N,N ′ -dimethylethylenediamine (dmen), 2,2 ′ -bipyridine-4,4 ′ -dicarboxylic acid (H2bpdc),
1,3-bis(diphenylphosphino)propane (dppp) and 1,1′-bis(diphenylphosphino)ferrocene (dppf)]. All the
complexes were characterized by IR and 1 H NMR spectroscopy and elemental analysis. The rhenium
complexes and their respective ligands were screened using the human leukaemia (MOLT-4) cell line
via the MTT assay. The results will be presented in the poster.
References
Cl
Ru
N
N
R
+
95
OC
OC
Re
1 2
1. A. Levina, A. Mitra, P. L. Lay, Metallomics 2009, 1, 458-470.
2. Y. K. Yan, M. Melchart, A. Habtemariam, P. J. Sadler, Chem. Commun. 2005, 4764-4776.
3. (a) J. Zhang, J. J. Vittal, W. Henderson, J. Wheaton, I. H. Hall, T. S. A. Hor, Y. K. Yan, J.
Organomet. Chem. 2002, 650, 123-132. (b) Y. K. Yan, S. E. Cho, K. A. Shaffer, J. E. Rowell, B. J.
Barnes, I. H. Hall, Pharmazie 2000, 55, 307-313. (c) W. Wang, Y. K. Yan, T. S. A. Hor, J. J. Vittal, J.
R. Wheaton, I. H. Hall, Polyhedron 2002, 21, 1991-1999.
X
L
CO
L