Book of Abstracts - Ruhr-Universität Bochum

P-16
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Conjugation of Rheniumtricarbonyl Bisimine Complexes to Polylactides -
Fluorescent Polymers for in vivo Tumour Diagnostics
Nadine E. Brückmann a and Peter C. Kunz* a
a Heinrich-Heine-University of Düsseldorf, Department of Inorganic Chemistry I,
Universitätsstr. 1, 40225, Düsseldorf, Germany. E-mail: peter.kunz@uni-duesseldorf.de
In order to improve current cancer pharmaceuticals, new polymer-based transport systems are being
developed that deliver the drug directly to the tumour, where it can subsequently be released.
Macromolecules can accumulate in tumours due to the EPR-effect. 1 Although polymers are now
widely used in therapeutic approaches, only a few examples of diagnostically applied polymerconjugates
exist. 2 Rheniumtricarbonyl bisimines e.g. are useful as dyes for fluorescence microscopy.
Their fluorescence emission lies in the visible light spectrum, resulting from a metal-to-ligand-chargetransfer
(MLCT). These transitions typically have large Stokes shifts, which makes the fluorescence
easily destinguishable from tissue autofluorescence. 3 Attachment of these rhenium cores to ligandfunctionalised
polylactides leads to biodegradable fluorescent polymers.
In particular, rheniumtricarbonyl complexes of 2,2’bipyridine (bipy), 1,10-phenanthroline (phen) as
well as dipyrido[3,2-a:2’,3’-c]phenazine (dppz) were prepared. Absorption and emission data were
ascertained, cytotoxicity was determined on A2780 ovarian cancer cell lines and the in vivo
localisation was examined by confocal microscopy. Investigations into their degradation kinetics are
currently ongoing.
References
1. H. Maeda, J. Wu, T. Sawa, Y. Matsamura, K. Hori, J. Cont. Rel. 2000, 65, 271-284.
2. A. Mitra, A. Nan, H. Ghandehari et al., Pharm. Res. 2004, 21(7), 1153-1159.
3. A. Amoroso, M. Coogan, J.E. Dunne et al., Chem. Commun. 2007, 29, 3066-3068.
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