Book of Abstracts - Ruhr-Universität Bochum

P-35
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Carbon Monoxide Release and Biological Properties of Manganese Tricarbonyl
Trispyrazolyl Complexes
Johanna Niesel, a Hendrik Pfeiffer, a and Ulrich Schatzschneider *a
a Ruhr-Universität Bochum, Lehrstuhl für Anorganische Chemie I, Universitätsstrasse 150, D-44801
Bochum, Germany. E-mail: johanna.niesel@rub.de
Carbon monoxide is an important small molecule messenger in the human body. 1 For its controlled
release to biological systems, transition metal carbonyl complexes can be utilized to exploit the
beneficial physiological effects of CO like vasodilatation and protection against oxidative stress. In
addition, cytotoxic activity of carbon monoxide against cancer cells and pathogenic microorganisms
has been established. In contrast to hydrolytic liberation of CO from metal carbonyl complexes,
photoactivated CO release will allow for a precise spatial and temporal control of its biological
activity. 2 Recently, we have identified [Mn(CO)3(tpm)] + with tpm = tris(1-pyrazolyl)methane as a
stable in aqueous solution and inactive against cancer cells in the dark. However, upon light activation
it efficiently kills HT29 human colon cancer cells. 3,4 To study the influence of the ligand system on the
CO release and the biological properties, manganese trispyrazolylcomplexes with variations on the
pyrazol rings 6 or the alpha carbon 7 were synthesized and their CO release efficiency as well as
biological activity against human breast cancer cells MCF7 and colon cancer cells HT-29 was
investigated.
References
1. S.W. Ryter, J. Alam, A.M.K. Choi, Physiol. Rev. 2006, 583-650.
2. U. Schatzschneider, Eur. J. Inorg. Chem. 2010, 10, 1451-1467.
3. J. Niesel, A. Pinto, H. W. Peindy N'Dongo, K. Merz, I. Ott, R. Gust, U. Schatzschneider, Chem.
Commun. 2008, 1798-1800.
4. H. Pfeiffer, A. Rojas, J. Niesel, U. Schatzschneider, Dalton Trans. 2009, 4292-4298.
5. K. Meister, J. Niesel, U. Schatzschneider, N. Metzler-Nolte, D.A. Schmidt, M. Havenith, Angew.
Chem. 2010, 122, 3382-3384; Angew. Chem. Int. Ed. 2010, 49, 3310-3312.
6. D.L. Reger, R.D. Sommer, J. Organomet. Chem. 2000, 607, 120-128.
7. B.J. Liddle, J.R. Gardinier, J. Org. Chem. 2007, 72, 9794-9797.
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