Book of Abstracts - Ruhr-Universität Bochum

P-15
ISBOMC `10 5.7 – 9.7. 2010 Ruhr-Universität Bochum
Synthesis and Characterisation of Palladium Bioconjugates
Jan Dittrich a and Nils Metzler-Nolte* a
a Ruhr-University Bochum, Faculty of Chemistry and Biochemistry, Department of
Inorganic Chemistry I, Universitätsstr. 150, 44801 Bochum, Germany
E-mail: Jan.Dittrich@rub.de
Some transition metals like gold and platinum play a major role in anti-tumor research. 1,2 Palladium is
a homologue element of platinum with related chemical behaviour, but is not in focus of cancer
research until now. The ligand exchange rate of palladium is much higher than the one of platinum,
consequently cispalladium would not work as an anticancer drug. The goal we are striving for are
palladium bioconjugates like 1. A suitable metal complex is formed from a cyclometallated palladiumazide
3 and methyl 2-isocyanoacetate, which undergo a [3+2] cycloaddition reaction to yield after
rearrangement an ester functionalised palladium-tetrazole. After saponification this compound can be
linked to an amino acid or peptide, both in solution and on solid phase. The compounds were
characterized by multidimensional and multinuclear NMR techniques, mass spectrometry and IR
spectroscopy.
References
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1. I. Ott, Coord. Chem. Rev. 2009, 52, 763-770.
2. Z. Guo, P.J. Sadler, Angew. Chem. Int. Ed. Engl. 1999, 38, 1512-1531.
3. Y.J. Kim, X. Chang, J.T. Han, M.S. Lim, S.W. Lee, Dalten Trans. 2004, 3699-3708.
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