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Table 1. Biological assays of the synthesized analogsAnalogs of the Peptide Sequence Ser 558 –Gln 565APTT%ValueFVIIIaControl A 39.2 49.0Control B 24.91. Ser 558 –Val 559 –Asp 560 –Gln 561 –Arg 562 –Gly 563 –Asn 564 –Gln 565 -OH 45.0 7.42. Ser 558 –Val 559 –Asp 560 –Gln 561 –Arg 562 –Gly 563 –Asn 564 –Gln 565 –NH 2 44.3 15.73. Ser 558 –Val 559 –Asp 560 –Gln 561 –Arg 562 –Gly 563 –Asp 564 –Gln 565 –OH 44.2 8.94. Cyclo[-Ser 558 –Val 559 –Asp 560 –Gln 561 –Arg 562 –Gly 563 –Asn 564 –Gln 565 ] 40.1 7.55. Ser 558 –Val 559 –Asp 560 –Gln 561 –Arg 562 –NPhe 563 –Asn 564 –Gln 565 –OH 44.5 5.46. Gln 561 –Arg 562 –NPhe 563 –Asn 564 –Gln 565 –OH 43.1 7.37. Arg 562 –NPhe 563 –Asn 564 –Gln 565 –OH 42.4 13.18. NPhe 563 –Asn 564 –Gln 565 –OH 41.1 5.5AcknowledgementsThis Research Project is co-financed: 80% by European Union – European Social Fund and 20% byGeneral Secretary of Research & Technology (PENED 03ED569). Also, we thank the pharmaceuticalcompany SANOFI-AVENTIS for the financial fund.References1. Fay, P., Jenkins, V. Blood Reviews 19, 15-27 (2005).2. Obergfell, A., Sturm, A., Speer, C., et al. Platelets 17, 448- 453 (2006).3. Shen, B.W., Spiegel, P.C., Chang, C.H., et al. Blood 111, 1240-1247 (2008).4. Anastasopoulos, Ch., et al. In H. Lankinen (Ed), Peptides 2008 (Proceedings of the 30th EPS),Helsinki, Finland, (2009), 416-417.5. Minors, D. Anaesthesia and Intensive Care Medicine 8, 214-216 (2007).6. Barrowcliffe, T.W., Raut, S., et al. Seminars in Thrombosis and Hemostasis 28, 247-255 (2002).365