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Solid-phase synthesis on the 2-Cl-Trt resin was performed by Fmoc-/t-Bu strategy bothusing standard methods of the sequential chain elongation and in a convergent manner [5],the corresponding fragments selection is marked in the table by the || sign.DIC, HOBt, HOAt, and PyBOP served as condensing agents, reactions were run inDMF and NMP. The conversion of reactions was estimated using the Kaiser test andbromophenol blue.The purification of the compounds obtained was carried out via preparative reversedphaseHPLC. Their purity turned to be not less than 95%. The molecular ion peaks inmass-spectra MALDI-TOF were in accordance with calculated peaks for all synthesizedpeptides.At the moment the peptides under discussion are undergoing biological tests on thebase of the Research Institute of Influenza situated in Saint-Petersburg.References1. De Clercq, E. Nature Rev. Microbiol. 2, 704-720 (2004).2. Kiselev, O.I., Deeva, E.G., Slita, A.V., Platonov, V.G. Anti-viral medications for influenza andacute respiratory disease therapy. Drug design based on polymer carriers. Publishing house ofInformation and Analysis Center “Vremya”, St-Petersburg, 2000, p.132. (Published in Russian).3. Trivedi, V.D., Cheng, S.-F., Wu, C.-W., Karthikeyan, R., Chen, C.-J., Chang, D.-K. ProteinEngineering 16, 4, 311-317 (2003).4. Ghanem, A., Mayer, D., Chase, G., Tegge, W.F., Ronald, K.G., García-Sastre, A., Schwemmle, M.Journal of Virology 81, 14, 7801-7804 (2007).5. Chan, W.C., White, P.D. Fmoc solid phase peptide synthesis, Oxford University press, 2004.549