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photolysis 82photoreaction 586photoswitchable amino acid 12phototriggers 82Pictet-Spengler reaction 92PKB/Akt 226plasmodium gallinaceum 352PNA 234, 608PNA building block functionalization206polyarginine 520polyethylene glycol linker 96polymere matrices 70positron emission tomography 338PPIase 24prediction algorithm 418pressure denaturation 284prion 84privileged structures 134pro position 370Procaspase-9 552prodrug 324proenkephalin 424proline 490proline analogues 470prolyl peptides 346proprotein convertases (PCs) inhibitors466prostate cancer 430protease 608protease inhibitor 232proteasome 496protecting groups 176, 208protein 418protein aggregation 280protein dimerization 600protein engineering 34, 178protein hydrolysate 540protein modificatin 278protein-ligand interactions 434protein-peptide interactions 332protein-protein mimics 238proteolysis 502proteolytic stability 440proteomics 560pseudoproline dipeptides 160p-triazinylphosphonium sulfonates 124purification 194pyrazinone 232pyrrolo 268Q-TOF 276quantum mechanics 2quercetin 322quinacrine 84racemization 120, 192radical scavenging activity 56radioactivity accumulation 590radiolabelled peptide 530radioligand binding 454Raman spectroscopy 588rapid alkalinization factor 412Ras 42receptor antagonist 244, 246receptor dimerization 96receptor selectivity 306receptors 88recognition 88reduction 102regiospecificity 586relaxin 158reorientation 246reproductive control drug 326rhodium 152RNA 608rytvela 256S-acyl isopeptide method 112SAR 210, 232, 256scaffold 264, 612scavenger 132secondary structure 580selective anticancer therapy 354selective disulphide formation 144selenocysteine 250self-assembled glycolipopeptide 626self-assembly 578, 628self-immolative linker 20semisynthetic protein 42serine protease 470, 472serine protease inhibitor 554serum 612serum amyloid A 288serum peptides 276SFTI-1 470, 472639

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