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Table 1. Folding dynamics of Ac-WITVTI-loop-KKIRVWTG-NH 2 peptides at 300Kloop = δ(Hε3) a K F 1/k F (µs) 1/k U (µs) Entry#HG or pG 5.66 ≥ 60 0.80509
<strong>Proceedings</strong> of the 31 st European Peptide SymposiumMichal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors)European Peptide Society, 2010Necrotic cells, %Two Short Peptides that Arise in Inflammation DemonstratedStrong Neuroprotective Effects In VitroVsevolod G. Pinelis 1 , Tatyana N. Storozhevykh 1 , Kristina V. Glebova 2 ,Tatyana N. Danyukova 2 , Yana E. Senilova 1 , Stanislav I. Schramm 2 ,and Nikolay F. Myasoedov 21 Laboratory of Membranology and Genetic Research, Scientific Center for ChildrenHealth, Russian Academy of Medical Sciences, Moscow, 119991, Russia; 2 Laboratory ofNeuropharmacology, Institute of Molecular Genetics, Russian Academy of Sciences,Moscow, 123182, RussiaIntroductionSeveral studies have shown that tripeptide N-acetyl-Pro-Gly-Pro (N-acetyl-PGP)endogenously derived from collagen or other extracellular matrix proteins is an importantmediator of inflammation in the lungs [1,2]. This activity is due to the ability of the peptideto activate neutrophils through chemokine receptors CXCR1 and CXCR2 [2]. Anotherpeptide, PGP, also demonstrated chemotactic activity, but weaker than N-acetyl-PGP [3]. Itis also known that cerebral ischemia progression in the brain leads to matrixmetalloproteinases activation and, perhaps, to accumulation of long-living products,especially Pro- and Gly-rich peptides [4]. Meanwhile, we have previously shown thatPGP-treatment has a neuroprotective effect after experimental focal brain ischemia in rats[5]. Based on these and some other data, we assume that ischemia-generated PGP-likepeptides can be actively involved both in inflammation and neuroprotection throughinteraction with neuronal or glial CXCR1/2. Thus, in this study we attempted to betterunderstand the nature of revealed neuroprotective effect using various in vitro models ofneuron damage, as well as cell cultures in which CXCR1/2 expression differs.Results and DiscussionTwo neuronal cell cultures one of which does not express CXCR1/2 (rat pheochromocytomaPC12 cell line) and the other one – well express CXCR1/2 (primary culture ofcerebellar granule neurons - CGNs) were used for modeling three different neuron damagemechanisms: 1) oxidative stress-stimulated necrosis (Oxidative stress model - PC12 cells,1 mM H 2 O 2 , 30 min); 2) growth factors deprivation-induced apoptosis (Deprivation model- CGNs, B-27 Supplements withdrawal, 24 h); and 3) glutamate receptor hyperactivation(Glu-toxicity model - CGNs, 100 μM Glu,1 h) resulting in both necrosis and100806040******PGPN-acetyl-PGP************200 0.1 1 10 100P e p t i d e, μMFig. 1. Cytoprotective effects of PGP andN-acetyl-PGP on neuronal PC12 cells afterH 2 O 2 -induced oxidative stress. ***p
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Peptides 2010Tales of PeptidesProce
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Peptides 2010Tales of PeptidesProce
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IntroductionWe had the distinct hon
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Scientific programIn planning the 3
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31 st EUROPEAN PEPTIDE SYMPOSIUMSep
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published by John Wiley & Sons as a
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The Josef Rudinger AwardThis award
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Young Investigators' SymposiumThe y
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xxiv
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Design of Peptidyl-Inhibitors for G
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Synthetic Antifreeze Glycopeptide A
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Synthesis and Oxidative Folding of
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Convergent Syntheses of Huprp106-12
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Bactericidal Activity of Small Beta
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Bradykinin Analogues Acylated on Th
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Antimicrobial Activity of Small 3-(
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Interaction of Curcumin with A-Synu
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Fluorescent and Luminescent Fusion
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Cellular Expression of the Human An
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2D IR Spectroscopy of Oligopeptides
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large, non-redundant subset of prot
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The aberrantly glucosylated peptide
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Table 1. Proline cis/trans ratios o
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Table 1. Yields, UV-vis absorption
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Table 1. Purity of the targeted tri
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processes are blocked. Interestingl
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(tb4 n ,1 m )MTII(tb1 n ,4 m )MTIIF
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Fig. 2. a) Part of the 400 MHz HR-M
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Once printed, the amino acid partic
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A) PSA, few seconds73B) PSA, 45 min
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short β strands. In contrast, nume
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neg. control Cs9-Rhd MM-218Fig. 2.
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Table 1. The general structure of t
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% ID in the liver 1 h p.i.100908070
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Peptidyl phosphoranes were first re
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obtained from the same sardines and
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MccJ25 variants were produced by si
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Fig. 2. Proposed signaling mechanis
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Table 1. mCD4-HS12 antiviral activi
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Proceedings of the 31 st European P
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Subject index(S)-2-(1-adamantyl)gly
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chip 18chiral triazine condensing r
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heat stress 348helical conformation
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O-acyl isopeptide method 112obesity
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SH2-ligands 210short collagen-relat
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Author indexAboye, Teshome Leta 142
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Chi, Hongfang 480Chiche, Laurent 6C
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Geronikaki, Athina 444Gessmann, Ren
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Kostova, Kalina 528Kotzia, Georgia
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Nagata, Koji 162Nagayev, Igor Yu. 5
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Salvarese, Nicola 518Sammet, Benedi
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Vauquelin, Georges 138Veiga, Ana Sa
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