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configuration (1’S, 1S, 3R) in the dimer 2a, and in the configuration (1’R, 1R, 3S) in thedimer 2b. The dose-response curves of the two constructs obtained in the cell proliferationassay are comparable, suggesting that the stereochemistry of the linker does notsignificantly affect the biological activity. Interestingly, the monomeric form of the Id1fragment 91-101 (1) has not decreased cell proliferation in the concentration range, inwhich its dimeric form has been found to be active (Figure 1). Therefore, converting theshort peptide from a monomer to a covalent homodimer has allowed obtaining an activecompound, probably due to increased avidity towards its biological target.AcknowledgmentsThis work was supported by the DFG (Emmy-Noether Grant CA296), the DAAD-Vigoni and in partby the EU FP6 Grant LSHM-CT-2006-037498.References1. Massari, M.E., Murre, C. Mol. Cell Biol. 20, 429-440 (2000).2. Ma, P.C., Rould, M.A., Weintraub, H., Pabo, C.O. Cell 77, 451-459 (1994).3. Perk, J., Iavarone, A., Benezra, R. Nat. Rev. Cancer 5, 603-614 (2005).4. Kiewitz, S.D., Cabrele, C. Biopolymers (Peptide Sci.) 80, 762-774 (2005).5. Kiewitz, S.D., Kakizawa, T., Kiso, Y., Cabrele, C. J. Peptide Sci. 14, 1209-1215 (2008).6. Beisswenger, M., Yoshiya, T., Kiso, Y., Cabrele, C. J. Peptide Sci. 16, 303-308 (2010).7. Pellegrino, S., Ferri, N., Colombo, N., Cremona, E., Corsini, A., Fanelli, R., Gelmi, M.L., Cabrele,C. Bioorg. Med. Chem. Lett. 19, 6298-6302 (2009).8. Cabrele, C., Clerici, F., Gandolfi, R., Gelmi, M.L., Molinari, F., Pellegrino, S. Tetrahedron 62,3502-3508 (2006).601