On the Spectrum

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From Chronnectivity To Chronnectopathy: Connectivity Dynamics of Typical Development Figure 5. Summary metrics and age- and sex- effects. 5 Summary metrics from the four dynamic connectivity states in relation to age and sex. Mean dwell time (MDT) represents how long an individual spends in a given state on average, and fraction of time (FT) is Figure the summed 5. Summary total time metrics spent in and a given age- state and over sex- the effects. course of Summary the measurement metrics period. from the For four age associations, positive beta coefficient (β) indicates older children spend more time in that particular state whereas negative beta coefficient (β) indicates younger children spend more time in a particular dynamic connectivity states in relation to age and sex. Mean dwell time (MDT) state. For sex analyses, positive beta coefficient (β) indicates girls spend more time in the state relative to boys, and negative beta coefficient (β) indicates that boys spend more time in the state relative to represents girls. Bar graphs how long indicate an individual the unstandardized spends in beta a given coefficients state on (β) average, with standard fraction error (S.E.) of from time regression models, and asterisks (*) indicate the results survived the false discovery rate (FDR) multiple comparison (FT) the correction summed threshold total time of spent pFDR = in 0.05. a given The rendering state over brain the maps course are of showing the measurement modularized positive (red) and negative (blue) connectivity for the corresponding dynamic states. period. For age associations, positive beta coefficient (β) indicates older children spend more time in that particular state whereas negative beta coefficient (β) indicates younger children spend more time in a particular state. For sex analyses, positive beta coefficient 107 34
Chapter 5 Figure 6. Summary metrics and autistic trait effects. 36 Summary metrics from the four dynamic connectivity states in relation to autistic traits. Mean dwell time (MDT) represents how long an individual spends in a given state on average, and fraction of time (FT) is the summed total time spent in a given state over the course of the measurement period. Positive beta coefficient (β) indicates that higher levels of autistic traits are associated with more time spent in a particular state; whereas negative beta coefficient (β) indicate lower levels of autistic traits are associated with more time spent in a particular state. Bar graphs indicate the unstandardized beta coefficients (β) with standard error (S.E.) from regression models, and Asterisks (*) indicate the results survived the false discovery rate (FDR) multiple comparison correction threshold of pFDR = 0.05. The rendering brain maps are showing modularized positive (red) and negative (blue) connectivity for the corresponding dynamic states. 108
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On the Spectrum the neurobiology of
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ISBN: 978-94-6233-336-9 © Laura Bl
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PROMOTIECOMMISSIE Promotoren Overig
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MANUSCRIPTS THAT FORM THE BASIS OF
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Chapter 1 10
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Chapter 1 Cuthbert, Garvey, Heinsse
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Chapter 1 folding of the brain into
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Chapter 1 beneficial for treatment
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Chapter 1 REFERENCES Achenbach, T.
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Chapter 1 Sonuga-Barke, E. J. S.
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IPart I: The neurobiology of autist
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Chapter 2 ABSTRACT Objective: Recen
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Chapter 2 Hardan 2010) and right pa
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Chapter 2 Statistical analysis To i
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Chapter 2 Gyrification Six regions
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Chapter 2 The association remained
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Chapter 2 Table 4. Autistic traits
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Chapter 2 While we found widespread
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Chapter 2 REFERENCES Amaral, D. G.,
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Chapter 2 Wallace, G. L., P. Shaw,
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Chapter 2 South-West of the Netherl
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Chapter 2 Supplementary Figure 1. F
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Chapter 2 Supplementary Figure 3. G
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Chapter 2 Supplementary Figure 5. C
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Chapter 2 Supplementary Table 1. No
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Chapter 2 Supplementary Table 3. Ca
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Cognitive functioning in children w
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Chapter 7 ABSTRACT Objectives: In c
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Chapter 7 profile analysis performe
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Chapter 7 have been demonstrated pr
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Chapter 7 Next, we examined associa
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Chapter 7 Table 2 Brain morphology
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Chapter 7 Table 3 Cortical thicknes
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Chapter 7 Our finding was suggestiv
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Chapter 7 Using empirically defined
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Chapter 7 Fischl, B. and A. M. Dale
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Chapter 7 Supplement Table 1 Brain
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IIIPart III
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Chapter 8 190
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Chapter 8 stable relationships, and
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Chapter 8 gyrification changes in p
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Chapter 8 genetic or environmental
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Chapter 8 diseases, according to th
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Chapter 8 ability may be even more
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Chapter 8 symptoms could be more sp
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Chapter 8 association of maternal v
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Chapter 8 REFERENCES Abrahams, B. S
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Chapter 8 Goddard, M. N., S. van Ri
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Chapter 8 Sebat, J., B. Lakshmi, D.
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SSummary Samenvatting
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Summary SUMMARY Despite evidence fr
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Summary along a continuum were used
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Samenvatting SAMENVATTING Genetisch
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Samenvatting jonge kinderen die zic
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Addendum Mous SE, Schoemaker NK, Bl
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Addendum Zoeken in andere databases
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Addendum School of Women’s and In
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Addendum Graag wil ik Dr. Marion Sm
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Addendum hebben. Dank in het bijzon
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