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On the Spectrum

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A Prospective Study of Fetal Head Growth in Children, Autistic Traits and Autism <strong>Spectrum</strong> Disorder<br />

Meta-analysis<br />

Analyses were conducted separately for each cohort. Subsequently, a pooled estimate was<br />

obtained, taking into account sample size and direction of effect, using Metal (Willer, Li and<br />

Abecasis 2010).<br />

RESULTS<br />

Demographics<br />

Table 1 presents characteristics of <strong>the</strong> study samples from both cohorts used for <strong>the</strong> main<br />

analyses.<br />

3<br />

Non-response analysis<br />

In <strong>the</strong> Generation R Study, characteristics of mo<strong>the</strong>rs of 4,533 children included in <strong>the</strong><br />

analyses were compared to those of mo<strong>the</strong>rs of 4,201 children excluded due to missing SRS<br />

data. The excluded mo<strong>the</strong>rs were younger (28.0 ± 5.5 years vs. 31.1 ± 4.6, t = 28.5, p < .001),<br />

less well educated (38.1% vs. 61.3% higher education; χ 2 = 221.2, p < .001) and less likely to<br />

be of Dutch origin (31.8% vs. 62.7% Dutch; χ 2 = 1002.4, p

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