On the Spectrum

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6 Cognitive functioning in children with internalizing, externalizing and dysregulation problems: a population-based study Laura M.E. Blanken, Tonya White, Sabine E. Mous, Maartje Basten, Ryan L. Muetzel, Vincent W.V. Jaddoe, Marjolein Wals, Jan van der Ende, Frank C. Verhulst, Henning Tiemeier European Child & Adolescent Psychiatry, accepted for publication
Chapter 6 ABSTRACT Background: Psychiatric symptoms in childhood are closely related to neurocognitive deficits. However, it is unclear whether internalizing and externalizing symptoms are associated with general or distinct cognitive problems. Methods: We examined the relation between different types of psychiatric symptoms and neurocognitive functioning in a population-based sample of 1,177 school-aged children. Internalizing and externalizing behavior was studied both continuously and categorically. For continuous, variable-centred analyses, broadband scores of internalizing and externalizing symptoms were used. However, these measures are strongly correlated, which may prevent identification of distinct cognitive patterns. To distinguish groups of children with relatively homogeneous symptom patterns, a latent profile analysis of symptoms at age 6 yielded four exclusive groups of children: a class of children with predominantly internalizing symptoms, a class with externalizing symptoms, a class with co-occurring internalizing and externalizing symptoms, that resembles the CBCL Dysregulation profile and a class with no problems. Five domains of neurocognitive ability were tested: attention/executive functioning, language, memory and learning, sensorimotor functioning, and visuospatial processing. Results: Consistently, these two different modelling approaches demonstrated that children with internalizing and externalizing symptoms show distinct cognitive profiles. Children with more externalizing symptoms performed lower in the attention/executive functioning domain, while children with more internalizing symptoms showed impairment in verbal fluency and memory. In the most severely affected class of children with internalizing and externalizing symptoms, we found specific impairment in the sensorimotor domain. Conclusions: This study illustrates the specific interrelation of internalizing and externalizing symptoms and cognition in young children. 134
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On the Spectrum the neurobiology of
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ISBN: 978-94-6233-336-9 © Laura Bl
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PROMOTIECOMMISSIE Promotoren Overig
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MANUSCRIPTS THAT FORM THE BASIS OF
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Chapter 1 10
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Chapter 1 Cuthbert, Garvey, Heinsse
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Chapter 1 folding of the brain into
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Chapter 1 beneficial for treatment
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Chapter 1 REFERENCES Achenbach, T.
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Chapter 1 Sonuga-Barke, E. J. S.
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IPart I: The neurobiology of autist
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Chapter 2 ABSTRACT Objective: Recen
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Chapter 2 Hardan 2010) and right pa
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Chapter 2 Statistical analysis To i
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Chapter 2 Gyrification Six regions
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Chapter 2 The association remained
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Chapter 2 Table 4. Autistic traits
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Chapter 2 While we found widespread
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Chapter 2 REFERENCES Amaral, D. G.,
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Chapter 2 Wallace, G. L., P. Shaw,
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Chapter 2 South-West of the Netherl
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Chapter 2 Supplementary Figure 1. F
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Chapter 2 Supplementary Figure 3. G
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Chapter 2 Supplementary Figure 5. C
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Chapter 2 Supplementary Table 1. No
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Chapter 2 Supplementary Table 3. Ca
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3 A Prospective Study of Fetal Head
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A Prospective Study of Fetal Head G
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Chapter 4 ABSTRACT Background: Auti
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Chapter 4 An important trend concep
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Chapter 7 Fischl, B. and A. M. Dale
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Chapter 7 Supplement Table 1 Brain
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IIIPart III
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Chapter 8 190
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Chapter 8 stable relationships, and
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Chapter 8 gyrification changes in p
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Chapter 8 genetic or environmental
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Chapter 8 diseases, according to th
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Chapter 8 ability may be even more
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Chapter 8 symptoms could be more sp
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Chapter 8 association of maternal v
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Chapter 8 REFERENCES Abrahams, B. S
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Chapter 8 Goddard, M. N., S. van Ri
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Chapter 8 Sebat, J., B. Lakshmi, D.
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SSummary Samenvatting
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Summary SUMMARY Despite evidence fr
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Summary along a continuum were used
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Samenvatting SAMENVATTING Genetisch
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Samenvatting jonge kinderen die zic
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Addendum Mous SE, Schoemaker NK, Bl
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Addendum Zoeken in andere databases
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Addendum School of Women’s and In
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Addendum Graag wil ik Dr. Marion Sm
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Addendum hebben. Dank in het bijzon
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On the Spectrum

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