On the Spectrum

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5 From Chronnectivity To Chronnectopathy: Connectivity Dynamics of Typical Development And Autistic Traits Laura M.E. Blanken*, Ryan L. Muetzel * , Barnaly Rashid*, Robyn Miller, Eswar Damaraju, Mohammad R. Arbabshirani, Erik B. Erhardt, Frank C. Verhulst, Aad van der Lugt, Vincent W. V. Jaddoe, Henning Tiemeier, Tonya White*, Vince Calhoun *These authors contributed equally Submitted for publication
Chapter 5 ABSTRACT Autism spectrum disorder is often studied with little context of typical brain development. In addition, most functional connectivity studies operate under the assumption that connectivity remains static over multiple minutes. We hypothesized that relaxing this stationarity assumption would reveal novel features of both autism and typical brain development. We employed a ‘chronnectomic’ (recurring, time-varying patterns of connectivity) approach to evaluate transient states of connectivity using resting-state functional MRI in a sample of 774 6-to-10 year-old children. Whole-brain dynamic connectivity was evaluated using a sliding window technique, and revealed four transient states. Inter-domain connectivity increased with age in modularized dynamic states, illustrating an important pattern of connectivity associated with the developing brain. Furthermore, we demonstrate that higher levels of autistic traits were associated with more time spent in a globally disconnected state. These results provide a road map to the chronnectomic organization of the brain and also suggest that children with autistic traits exhibit delayed characteristics of functional brain maturation. 98
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On the Spectrum the neurobiology of
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ISBN: 978-94-6233-336-9 © Laura Bl
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PROMOTIECOMMISSIE Promotoren Overig
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MANUSCRIPTS THAT FORM THE BASIS OF
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Chapter 1 10
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Chapter 1 Cuthbert, Garvey, Heinsse
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Chapter 1 folding of the brain into
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Chapter 1 beneficial for treatment
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Chapter 1 REFERENCES Achenbach, T.
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Chapter 1 Sonuga-Barke, E. J. S.
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IPart I: The neurobiology of autist
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Chapter 2 ABSTRACT Objective: Recen
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Chapter 2 Hardan 2010) and right pa
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Chapter 2 Statistical analysis To i
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Chapter 2 Gyrification Six regions
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Chapter 2 The association remained
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Chapter 2 Table 4. Autistic traits
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Chapter 2 While we found widespread
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Chapter 2 REFERENCES Amaral, D. G.,
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Chapter 2 Wallace, G. L., P. Shaw,
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Chapter 2 South-West of the Netherl
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Cognitive functioning in children w
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Chapter 7 ABSTRACT Objectives: In c
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Chapter 7 profile analysis performe
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Chapter 7 have been demonstrated pr
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Chapter 7 Next, we examined associa
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Chapter 7 Table 2 Brain morphology
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Chapter 7 Table 3 Cortical thicknes
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Chapter 7 Our finding was suggestiv
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Chapter 7 Using empirically defined
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Chapter 7 Fischl, B. and A. M. Dale
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Chapter 7 Supplement Table 1 Brain
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IIIPart III
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Chapter 8 190
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Chapter 8 stable relationships, and
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Chapter 8 gyrification changes in p
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Chapter 8 genetic or environmental
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Chapter 8 diseases, according to th
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Chapter 8 ability may be even more
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Chapter 8 symptoms could be more sp
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Chapter 8 association of maternal v
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Chapter 8 REFERENCES Abrahams, B. S
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Chapter 8 Goddard, M. N., S. van Ri
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Chapter 8 Sebat, J., B. Lakshmi, D.
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SSummary Samenvatting
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Summary SUMMARY Despite evidence fr
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Summary along a continuum were used
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Samenvatting SAMENVATTING Genetisch
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Samenvatting jonge kinderen die zic
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Addendum Mous SE, Schoemaker NK, Bl
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Addendum Zoeken in andere databases
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Addendum School of Women’s and In
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Addendum Graag wil ik Dr. Marion Sm
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Addendum hebben. Dank in het bijzon
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On the Spectrum

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