On the Spectrum

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nalysis did not reveal any FDR-corrected effect of autistic traits. However, From Chronnectivity To Chronnectopathy: Connectivity Dynamics of Typical Development of the effects remained the same as the original analysis (with 774 subjects). Figure S7: Summary metrics and autistic trait effects. 5 . Summary metrics from the 4 dynamic connectivity states in relation to autistic traits after removing subjects with autistic traits and ASD. Positive beta coefficient (β) indicates that higher levels of autistic traits are associated with more time spent in a particular state, whereas negative beta coefficient (β) indicate lower levels of autistic traits are associated with more time spent in a particular state. Bar graphs indicate the unstandardized beta coefficients (β) from regression models. The rendering brain maps are showing modularized positive (red) and negative (blue) connectivity for the corresponding dynamic states. Summary metrics and autistic trait effects. Summary metrics from the 4 nnectivity states in relation to autistic traits after removing subjects with s and ASD. Positive beta coefficient (β) indicates that higher levels of autistic sociated with more time spent in a particular state, whereas negative beta 3.4 IQ – adjusted analyses β) indicate As lower ASD is levels often of accompanied autistic traits by deficits are associated in cognition, with it was more important time spent to also rule out that lar state. Bar any graphs observed indicate associations the between unstandardized autistic traits beta and coefficients dynamic connectivity (β) from were not simply a reflection of general intellectual ability. Analyses associating autistic traits with dynamic odels. The rendering brain maps are showing modularized positive (red) and connectivity remained largely unchanged after adjusting for non-verbal IQ. Specifically, for ue) connectivity whole-matrix for the associations corresponding the dynamic four dynamic states. states, the general pattern of association remained. For the summary measure MDT, regression coefficients did not change more than 5%, suggesting the association is not confounded by IQ. 127
Chapter 5 Table S1. Participant characteristics Child characteristics (n=774) Age at MRI 7.99±1.01 Gender (% boy) 52.1 Ethnicity (%) Dutch 71.8 Other Western 6.5 Non-Western 21.7 Social Responsiveness Scale weighted total score 0.27±0.31 Age (years) at Social Responsiveness Scale assessment 6.2±0.46 Non-verbal IQ 102.0±14.5 Table S2. Peak activations of ICN spatial maps. Coordinate = max coordinate (mm) in MNI space, following LPI convention. ICN regions Peak (mm) X Y Z SUB-CORTICAL (SC) AUDITORY (AUD) IC: 37 Right Putamen [18 13 -6] IC: 13 Left Putamen [-27 0 3] Right Putamen [27 3 3] IC: 60 Right Thalamus [12 -30 9] IC:99 Left Superior Temporal Gyrus [-51-27 9] Right Superior Temporal Gyrus [60-18 9] VISUAL (VIS) IC:21 Left SMA [-3 6 48] IC: 51 Right SupraMarginal Gyrus [54-33 27] IC: 24 Right SupraMarginal Gyrus [-58-24 41] IC: 3 Left Precentral Gyrus [-36-24 57] IC: 6 Right Paracentral Lobule [6-30 66] IC: 8 Right Postcentral Gyrus [54 -9 33] Left Postcentral Gyrus [-51-12 33] SENSORIMOTOR (SM) IC: 53 Right Fusiform Gyrus [27-45-12] Left Fusiform Gyrus [-24-48 -9] IC: 77 Left Lingual Gyrus [-9-57 0] IC: 26 Left Calcarine Gyrus [-12-60 18] IC: 57 128
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On the Spectrum the neurobiology of
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ISBN: 978-94-6233-336-9 © Laura Bl
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PROMOTIECOMMISSIE Promotoren Overig
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MANUSCRIPTS THAT FORM THE BASIS OF
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Chapter 1 10
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Chapter 1 Cuthbert, Garvey, Heinsse
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Chapter 1 folding of the brain into
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Chapter 1 beneficial for treatment
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Chapter 1 REFERENCES Achenbach, T.
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Chapter 1 Sonuga-Barke, E. J. S.
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IPart I: The neurobiology of autist
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Chapter 2 ABSTRACT Objective: Recen
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Chapter 2 Hardan 2010) and right pa
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Chapter 2 Statistical analysis To i
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Chapter 2 Gyrification Six regions
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Chapter 2 The association remained
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Chapter 2 Table 4. Autistic traits
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Chapter 2 While we found widespread
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Chapter 2 REFERENCES Amaral, D. G.,
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Chapter 2 Wallace, G. L., P. Shaw,
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Chapter 2 South-West of the Netherl
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Chapter 2 Supplementary Figure 1. F
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Chapter 2 Supplementary Figure 3. G
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Chapter 2 Supplementary Figure 5. C
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Chapter 2 Supplementary Table 1. No
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Chapter 2 Supplementary Table 3. Ca
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3 A Prospective Study of Fetal Head
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A Prospective Study of Fetal Head G
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Chapter 7 Our finding was suggestiv
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Chapter 7 Using empirically defined
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Chapter 7 Fischl, B. and A. M. Dale
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Chapter 7 Supplement Table 1 Brain
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IIIPart III
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Chapter 8 190
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Chapter 8 stable relationships, and
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Chapter 8 gyrification changes in p
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Chapter 8 genetic or environmental
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Chapter 8 diseases, according to th
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Chapter 8 ability may be even more
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Chapter 8 symptoms could be more sp
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Chapter 8 association of maternal v
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Chapter 8 REFERENCES Abrahams, B. S
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Chapter 8 Goddard, M. N., S. van Ri
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Chapter 8 Sebat, J., B. Lakshmi, D.
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SSummary Samenvatting
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Summary SUMMARY Despite evidence fr
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Summary along a continuum were used
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Samenvatting SAMENVATTING Genetisch
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Samenvatting jonge kinderen die zic
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Addendum Mous SE, Schoemaker NK, Bl
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Addendum Zoeken in andere databases
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Addendum School of Women’s and In
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Addendum Graag wil ik Dr. Marion Sm
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Addendum hebben. Dank in het bijzon
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On the Spectrum

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