ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P3. Oligomolecular Ternary Cu(II) Complexes
with Bridging µ-N6, N7- or µ-N7, N9-(2, 6-diaminopurine)
C. Alarcón-Payer a , M. Brandi-Blanco b , D. Choquesillo-Lazarte c , A. Castiñeiras d ,
J. M. González-Pérez a , J. Niclós-Gutiérrez a
a
Department of Inorganic Chemistry, University of Granada, Fac. Pharmacy, Campus Cartuja, E-18071
Granada, Spain
e-mail: jniclos@ugr.es
b
Fakultät Chemie, Lehrstuhl für Bioanorganische Chemie, Technische Universität Dortmund, Otto-Hahn-
Strasse 6, D-44227 Dortmund, Germany
c
Laboratorio de Estudios Cristalográficos, IACT-CSIC, Edif. Inst Lopez-Neyra, PTCS. Avda. del Conocimiento
s/n, E-18100 Armilla, Granada, Spain
d
Department of Inorganic Chemistry, University of Santiago, Fac. Pharmacy, Campus Sur, E-15782 Santiago
de Compostela, Spain
2,6-diaminopurine (Hdap) takes part of a nucleoside analogue, the anti-HIV pro-drug amdoxovir. The
coordination behaviour of its free purine base is poorly documented. Working with free Hdap we have obtained
two oligo-molecular compounds with different bridging µ2-Hdap modes: {[Cu(µ2-EGTA)Cu(H2O)(µ-N7, N9-
H(N3)dap)]·nH2O}2 (1) and {[Cu(pdc)(µ-N6, N7-H(N9)dap)]·H(N9)dap ·0.5H2O}2 (2) where EGTA and pdc are
ethylene-bis(oxyethylenenitrilo)-tetraacetate(4-) or 2, 6-pyridine-dicarboxylate(2-) ligands, respectively. In 1 the
Cu-N9 and Cu-N7 bonds are reinforced by N3-H···O(coord.) and N6-H···O(coord.) interligand interactions. In 2
the –N6H2 group is involved in both the binucleating Cu-N6 bond and the N6-H···O(coord.) interligand
interaction, which reinforces the Cu-N7 bond.
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