ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
KL32. New Biomimetic Analagoues of Functional Fe/S-Clusters
F. Meyer a , J. Ballmann a , M. Fuchs a , S. Dechert a , E. Bill b , E. Bothe b , U. Ryde c
a
Institut für Anorganische Chemie, Georg-August-Universität Göttingen, Tammannstrasse 4, D-37077
Göttingen, Germany
email: franc.meyer@chemie.uni-goettingen.de
b
Max-Planck-Institut für Bioanorganische Chemie, Stiftstrasse 34–36, D-45470 Mülheim an der Ruhr, Germany
c
Department of Theoretical Chemistry, Lund University, Chemical Centre, S-22100 Lund, Sweden
Iron-sulfur cofactors are ubiquitous in biological systems and have been of prime importance in nature since the
beginning of terrestrial life. Their main role is electron transfer, but other functions (where iron-sulfur clusters
act as catalytic centers or sensors) are increasingly recognized – iron-sulfur clusters have thus been termed
"nature’s modular multipurpose structures" [1, 2].
The investigation of synthetic model complexes has provided valuable insight into the properties and electronic
structures of iron-sulfur cofactors [3]. Despite decades of research, however, many challenges and synthetic
targets have remained even for the smaller clusters, in particular those with a [2Fe-2S] core. Work in the field is
further stimulated by the recent discovery of various [2Fe-2S] cofactors with unusual ligand environment,
comprising, e.g., N-donor protein residues such as in biotin synthase [4, 5].
Some new developments in synthetic iron-sulfur chemistry will be reported, including the investigation of
secondary bonding interactions in biomimetic [2Fe-2S] clusters (A) [6], the preparation of new [2Fe-2S] clusters
with N-donor ligation and of reduced [2Fe-2S] + species [7, 8], as well as the first isolation and full
characterization of a Rieske-type [2Fe-2S] model complex (B) [9].
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Fe Fe
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Fe Fe
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A B
Acknowledgement: This work has been carried out in the framework of the DFG-funded International Research
Training Group "Metal Sites in Biomolecules: Structures, Regulation and Mechanisms" (IRTG 1422; see
www.biometals.eu)
References:
[1] H. Beinert, J. Biol. Inorg. Chem., 5, 2 (2000).
[2] H. Beinert, R. H. Holm, E. Münck, Science, 277, 653 (1997).
[3] P. V. Rao, R. H. Holm, Chem. Rev., 104, 527 (2004); and references therein.
[4] F. Berkovich, Y. Nicolet, J. T. Wan, J. T. Jarrett, C. L. Drennan, Science, 303, 76 (2004).
[5] J. Lin, T. Zhou, K. Ye, J. Wang, PNAS, 104, 14640 (2007).
[6] J. Ballmann, S. Dechert, E. Bill, U. Ryde, F. Meyer, Inorg. Chem., 47, 1586 (2008).
[7] J. Ballmann, X. Sun, S. Dechert, E. Bill, F. Meyer, J. Inorg. Biochem., 101, 305 (2007).
[8] J. Ballmann, S. Dechert, E. Bill, E. Bothe, F. Meyer, unpublished.
[9] J. Ballmann, A. Albers, S. Demeshko, S. Dechert, E. Bill, E. Bothe, U. Ryde, F. Meyer, submitted.
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