ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P42. The Investigation of Chelation of Isoflavones with Transition Metals
S. Dowling a , H. Hughes a , F. Regan b
a
Department of Chemical & Life Sciences, School of Science, Waterford Institute of Technology, Brownes Road,
Waterford, Ireland.
b
National Centre for Sensor Research, School of Chemical Sciences, Dublin City University, Glasnevin, Dublin
9, Ireland
Flavonoid metal chelates come from the chelating ability of flavonoids with metals such as Cu(II) and Fe(III).
The investigation of chelation with flavonoids, such as quercetin, has been performed in great detail but little has
been done with investigation of chelation of isoflavones with metals. The investigation of isoflavone metal
chelates would be useful to explain how isoflavones can mediate metal overload disorders such as Wilson’s
Disease [1]. Flavonoid metal chelates have often shown to have enhanced antioxidant potential in comparsion to
their free flavonoid forms so knowledge of their stoichiometries may optimise their antioxidant potentials. [2]
The aim of this work was the investigation of metals that can chelate with isoflavones and the stoichiometry of
successful isoflavone metal chelates. The chelation of isoflavones Genistein, Daidzein and Biochanin A were
investigated with respect to the metals Cd(II), Cu(II), Fe(III), Zn(II), Ni(II), Pb(II), Co(II) and Ge(IV).
Isoflavone metal chelate stoichiometry was determined with Cu(II) and Fe(III) using the mole ratio method and
UV/VIS spectroscopy.
References
[1]. Mira L., Fernandez M.T., Santos M., Rocha R., ncio M.H., Jennings K.R. 2002.
Interactions of Flavonoids with Iron and Copper Ions: A Mechanism for their Antioxidant Activity. Free Radical
Research 36:1199-1208.
[2]. Malesev D., Kuntic V. 2007. Investigation of metal-flavonoid chelates and the determination of flavonoids
via metal-flavonoid complexing reactions. Journal of the Serbian Chemical Society 72:921-939.
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