ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P93. Linkage Isomerism in Complexes of Uracil with cis-(NH3)2Pt 2+
A. Khutia and B. Lippert
Fakultät Chemie, Technische Universität Dortmund, 44227 Dortmund, Germany
e-mail: akhutia@gmail.com
The coordination chemistry of Pt II with the simple nucleobase uracil provides a wealth of binding patterns.
Interest in these patterns relates, among others, to Pt antitumor agents (“platinum pyrimidine blues”[1]) and
supramolecular chemistry (“metallacalix[n]arenes”[2, 3]). The existence of bis(ligand) complexes of a metal
containing two identical ligands bonded to the metal through different sites (“linkage isomers”) is a relatively
rare case in coordination chemistry and relates to basic questions such as their formation, chemical properties of
the individual isomers and their mutual interference respectively.
NH
3
3 1
N NH
_____________________________________________________________________
212
O
H 3N
1
N
Pt
H 3N
1
O
Here we report on cis-(NH3)2Pt(UH-N1)(UH-N3), 1.5H2O (1), a neutral complex containing the two tautomers of
the uracil anion (UH) bonded simultaneously. The compound was synthesized in a stepwise manner from cis-
(NH3)2Pt(UH-N1)Cl and neutral uracil (UH2) at pH = 4-5 in water. The compound has been characterized by 1 H-
NMR spectroscopy (1-D; pD dependence) and elemental analysis. A unique feature of the title compound is the
isotopic exchange of the proton at C5 for deuterium when kept in D2O.
Acknowledgement: A. Khutia thanks the International Max-Planck Research School in Chemical Biology
(IMPRS-CB); Dortmund for a fellowship.
References:
[1] J.P. Davidson, P.J. Faber, R.G. Fischer, Jr., S. Mansy, H.J. Peresie, B. Rosenberg, L. VanCamp, Cancer
Chemother. Rep. Part I, 59, 287 (1975).
[2] H. Rauter, E.C. Hillgeris, A. Erxleben, B. Lippert, J. Am. Chem. Soc., 116, 616 (1994).
[3] E.G. Bardaji, E. Freisinger, B. Costisella, C.A. Schalley, W. Brüning, M. Sabat, B. Lippert, Chem. Eur. J.,
13, 6019 (2007).
O
O