ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
P58. Synthesis and Characterization of Dibutyltin(IV) Complexes with
O-donor Ligands Derivatives
M. Gajewska, a M. F.C. Guedes da Silva, a, b A. J. L. Pombeiro a
a
Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, TU Lisbon, Av. Rovisco Pais,
1049–001 Lisbon, Portugal
e-mail: magigajewska@yahoo.co.uk
b
Universidade Lusófona de Humanidades e Tecnologias, ULHT Lisbon, Av. do Campo Grande, 376,
1749-024, Lisbon, Portugal
Among main group metal compounds organotin(IV) derivatives occupy a relevant position in view of their
potential antitumour effects, since some of them show biological activity with relatively low toxicity [1, 2]. A
large number of organotin(IV) derivatives with bidentate O-donor ligands, [1-7] including N-substituted
hydroxamic acids, has been prepared and their in vitro antitumor activities (against a series of human tumor cell
lines) which, in some cases, are identical to, or even higher than, that of cisplatin, are well recognized. Although
mononuclear dibutyltin complexes, i.e. those with the organo-ligands having a long carbon chain, are the lead
compounds in terms of activity [4, 5] the search for other tin compounds with improved solubility mainly in
alcohols and/or even in water, is essential in view of their possible biological application.
In pursuit of our interest [3, 4] on diorganotin(IV) acceptors and O-donor ligands and derivatives, we extended
our studies to other hydroxamic-type molecules as well as N-, P- containing ligands. In our work we are using
bifunctional hydroxamic acid, which combines both oxime and hydroxamic HON-groups in one molecule. The
obtained compounds were characterized by FT-IR, 1 H, 13 C, and 119 Sn NMR. Evidence for the formation of
polynuclear organotin derivatives will be presented.
Acknowledgement: This work has been partially supported by the Foundation for Science and Technology
(FCT), grant BPD/32522/2006 and its POCI 2010 programme (FEDER funded).
References:
[1] A.J. Crowe, Antitumour activity of tin compounds, in: S.P. Fricker (Ed.), Metal Compounds in Cancer
Therapy, Chapman & Hall, London, 1994, pp. 147–179.
[2] M. Gielen, Coord. Chem. Rev. 151 (1996) 41.
[3] Q. Li, M.F.C. Guedes da Silva, A.J.L. Pombeiro, Chem. Eur. J. 10 (2004) 1456.
[4] Q. Li, M.F.C. Guedes da Silva, Z. Jinghua, A.J.L. Pombeiro, J. Organometal. Chem. 689 (2004) 4584.
[5] M. Gielen, App. Organomet. Chem. 16 (2002) 481, and references therein.
[6] X. Shang, J.Cui, J.Wu, A. J.L. Pombeiro, Q. Li, J. Inorg. Biochem. 102 (2008) 901
[7] X. Shang, J.Wu, A.J.L. Pombeiro, Q. Li, Appl. Organometal. Chem .21 (2007) 919
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