ISBN: 978-83-60043-10-3 - eurobic9

Eurobic9, 2-6 September, 2008, Wrocław, Poland
SL23. Synthesis and Reactivity Studies of Model Complexes for Dinuclear
Active Sites in Metalloenzymes
M. Jarenmark, a H. Carlsson, a M. Haukka b , A.A. Shteinman c and E. Nordlander a
a Inorganic Chemistry Research Group, Department of Chemical Physics,Center for Chemistry and Chemical
Engineering, Lund University, Box 124, SE-221 00, Sweden
b Department of Chemistry, University of Joensuu, Box 111, FI-80101 Joensuu, Finland
c Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow
Region142432, Russia
e-mail: Ebbe.Nordlander@chemphys.lu.se
Metalloenzymes with dinuclear active sites are prevalent in Nature. The active sites have common structural
traits; for example, structural features shared by most such enzymes include the presence of one or two bridging
carboxylate bridges and one or two exogenous oxygen-containing (oxo-, hydroxo or water) bridges [1]. Despite
these structural resemblances, the mechanistic diversity of this class of enzymes is striking. Utilizing a number
of framework ligands that have been designed to permit the structural emulation of most dinucear
metalloenzymes [2,3], we have prepared a number of active site mimics that are not only structural, but in
several cases also functional, model complexes for a number of enzymes, in particular hydrolases and
monooxygenases. This lecture will highlight a number of examples of this research, including model complexes
for the active sites of soluble methane monooxygenase, urease, zinc phosphotriesterase and purple acid
phosphatases.
Acknowledgements: The authors would like to thank the Swedish research council (VR) for financial support.
This research is carried out within the framework of the international graduate school ‘Metal sites in
biomolecules: structures, regulation and mechanisms’ (www.biometals.eu).
References:
[1] M. Jarenmark, H. Carlsson, E. Nordlander, Comptes Rendus Chimie, 10, 433 (2007).
[2] H. Carlsson, M. Haukka, A. Bosseksou, J.-M. Latour, E. Nordlander, Inorg. Chem., 43, 8252 (2004).
[3] M. Jarenmark, S. Kappen, M. Haukka E. Nordlander, Dalton Trans., 993 (2008).
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